PREPARATION AND CHARACTERIZATION OF DOXORUBICIN-LOADED MAGNETIC ANTICANCER NANOPARTICLES  

作　　者：LV Fengjiao LIN Huaxiang CHEN Xiaogeng XU Xiaoping 

机构地区：[1]School of Chemistry and life sciences, Quanzhou Normal University Quanzhou,362000, China [2]School of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China [3]Fujian Provincial Hospital Fuzhou 350000, China

出　　处：《Chinese Journal of Reactive Polymers》2007年第1期96-100,共5页中国反应性高分子（英文版）

基　　金：Science and Technology Ministry of Fujian (2005I010)

摘　　要：Doxorubicin（ADM）-loaded magnetic anticancer nanoparticles, using Fe3O4 as core, doxorubicin as model drug and polyvinylpyrrolidone （PVP） as matrix, were prepared by inverse emulsion polymerization. The experimental results showed that the average diameter of Fe3O4 particles was 19.8nm. The X-ray diffraction itzdicated that the prepared Fe3O4 particle was pure cubic Fe3O4, The results obtained by SEM showed the magnetic nanoparticles under optimal operating condition had a smooth spherical surface, LLS showed an average size of 78. 7nm. And IR results demonstrated that they consisted of ADM, PVP and Fe3O4.Doxorubicin(ADM)-loaded magnetic anticancer nanoparticles,using Fe3O4 as core, doxorubicin as model drug and polyvinylpyrrolidone (PVP) as matrix, were prepared by inverse emulsion polymerization. The experimental results showed that the average diameter of Fe3O4 particles was 19.8nm. The X-ray diffraction indicated that the prepared Fe3O4 particle was pure cubic Fe3O4. The results obtained by SEM showed the magnetic nanoparticles under optimal operating condition had a smooth spherical surface , LLS showed an average size of 78.7nm. And IR results demonstrated that they consisted of ADM, PVP and Fe3O4.

关 键 词：Magnetic nanoparticles POLYVINYLPYRROLIDONE Inverse emulsion polymerization. 

分 类 号：O63[理学—高分子化学]