海藻酸钠-壳聚糖-海藻酸钠生物微胶囊的制备  

Preparation of Sodium Alginate-chitosan-alginate Biomicrocapsule

作　　者：王家荣[1] 金谊[1] 刘望才[1] 高浩其[1] 

机构地区：[1]宁波工程学院化学工程学院,浙江宁波315016

出　　处：《宁波大学学报（理工版）》2007年第4期516-519,共4页Journal of Ningbo University：Natural Science and Engineering Edition

基　　金：宁波市青年博士基金(2005A61001)

摘　　要：采用两步法制备了海藻酸钠-壳聚糖-海藻酸钠(ACA)生物微胶囊,并考察了氯化钙浓度、海藻酸钠浓度、壳聚糖浓度及其pH值以及柠檬酸钠溶液pH值对微胶囊性能的影响.实验结果表明:胶囊粒径随氯化钙浓度和海藻酸钠浓度的增加而增大,胶囊的膜厚随壳聚糖浓度的增加而增厚,随壳聚糖溶液pH值的增加而降低;而在胶囊液化处理过程中,柠檬酸钠溶液的pH值对微胶囊的机械强度有很大的影响.当氯化钙浓度为1.5%,海藻酸钠浓度为2%,壳聚糖浓度和pH值分别为1.5%和5.0及柠檬酸钠溶液的pH值为7.2时,可制得粒径为2.65mm、机械强度为150mN的ACA生物微胶囊。In this paper, sodium alginate-chitosan-alginate （ACA） microcapsule is prepared using two-step method. The influence of concentration of calcium chloride, sodium alginate and chitosan, pH of chitosan and sodium citrate on the property of microcapsule is studied. The results show that the size of microcapsule increases with the concentration of sodium alginate and calcium chloride. The thickness of the microcapsule＇s membrane increases with the concentration of chitosan, and decreases with the pH of chitosan. During liquidization of the microcapsule, the pH of sodium citrate influences the mechanical strength. The microcapsule with the diameter of 2.65 mm and the mechanical strength of 150 mN are prepared when the concentration level of calcium chloride, sodium alginate and chitosan are at 1.5 %, 2 % and 1.5 %, respectively, and pH of chitosan and sodium citrate are at 5.0 and 7.2, respectively.

关 键 词：海藻酸钠 壳聚糖 生物微胶囊 

分 类 号：O648.17[理学—物理化学]