银杏萜内酯提取分离工艺研究  

Study on the Technology for Extraction and Isolation of Ginkgolidcs

作　　者：李保民[1] 宋亚冰[1] 袁橙[1] 吕加南[1] 刘勇林[2] 孙红[2] 宗志敏[1] 肖红斌[3] 

机构地区：[1]中国矿业大学化工学院,江苏徐州221008 [2]徐州医学院生理学教研室,江苏徐州221002 [3]中国科学院大连化学物理研究所,辽宁大连116023

出　　处：《化工时刊》2007年第12期21-24,共4页Chemical Industry Times

基　　金：江苏省徐州市科技发展基金项目(6H070047)

摘　　要：银杏内酯A、B、C及白果内酯(文中简称GA、GB、GC和BB)分子极性依次增强。因此,不同极性的有机溶剂对4种银杏萜内酯有不同的选择溶解性。通过丙酮,乙酸乙酯与乙醇三级溶解并为每一级溶解液匹配合适的柱层析吸附剂与洗脱液,从银杏提取物中分离纯化极有药用价值的银杏萜内酯。结果表明,本方法可将银杏内酯的纯度由6%提高至80%以上,并可将它们逐一分离。Ginkgolide A, B, C and bilobalide （GA,GB,GC and BB for short） had different polarities and could be dissolved in different organic solvents. EGB was dissolved by acetone, ethyl acetate and ethyl alcohol in turn and then dealed them with column chromatography, GA, GB, GC and BB valuable in medicine could be got, which concentrations were over 80% and they could be separated one by one.

关 键 词：银杏萜内酯 溶解 柱色谱 

分 类 号：R284[医药卫生—中药学]