氯硝柳胺悬浮剂的毒性评价  

Evaluation of toxicity of suspension concentrate of niclosamide

作　　者：戴建荣[1] 梁幼生[1] 李洪军[1] 唐建霞 朱荫昌[1] 

机构地区：[1]江苏省血吸虫病防治研究所,无锡214064

出　　处：《中国血吸虫病防治杂志》2007年第6期415-417,共3页Chinese Journal of Schistosomiasis Control

基　　金：江苏省自然科学基金(BK2006024);江苏省科技厅公益专项(BM2006712);江苏省卫生厅项目(X200504)

摘　　要：目的评价氯硝柳胺悬浮剂的毒性,为现场大规模应用灭螺提供依据。方法按照中华人民共和国国家标准GB15670-1995《农药登记毒理学试验方法》和鱼类毒性试验方法进行。结果经口、经皮肤的LD50雌、雄性大鼠均>5000mg/kg,经呼吸道的LC50雌、雄性大鼠均>5000mg/m3,该药经口、经皮肤、经呼吸道毒性均属微毒类药物;兔眼用药后,观察期内无不良反应,对眼无刺激性;皮肤用药后对皮肤无刺激性。与氯硝柳胺原药、氯硝柳胺乙醇胺盐原药和氯硝柳胺乙醇胺盐可湿性粉剂相比,氯硝柳胺悬浮剂对鱼急性毒性最低。结论氯硝柳胺悬浮剂属微毒类药物,对鱼的毒性低于其乙醇胺盐可湿性粉剂,适合于现场应用。Objective To evaluate the toxicity of suspension concentrate of niclosamide （SCN） for molluscicide in the field. Methods According to the state standard of the People＇ s Republic of China ＂The methods of toxicity test for agriculture register＂, GB15670-1995, the experiments of acute toxicity on rats and fish were carried out. Results LD50（s） of SCN via mouth and skin with rats were more than 5 000 mg/kg respectively, and LC50（s） of SCN via inbreathe with rats were more than 5 000 mg/m^3. Based on the classification of appraising criterion on acute toxicity test, it belonged to a feebleness toxicity degree. The eye and the skin stimulating tests with rabbits showed that it did not irritate the eyes and the skin. For fish, its acute toxicity was slightly lower than that of pure niclosamide, and markedly lower than that of pure niclosamide ethanolamine salt and WPN. Conclusions SCN belongs to a feebleness toxicity degree and has a lower toxicity to fish. It should be a useful molluscicide in endemic areas of schistosomiasis.

关 键 词：钉螺 氯硝柳胺 悬浮剂 毒性 

分 类 号：R383.24[医药卫生—医学寄生虫学]