郑州地区汉族人群2型糖尿病并发冠心病患者与对氧磷酶2基因311Cys-Ser多态性的关系  

Association of paraoxonase 2 C311S gene polymorphism with type Ⅱ diabetes mellitus complicated with coronary heart disease in population of Han nationality of Zhengzhou

作　　者：钱书虹[1] 钱庆文[2] 王诗瑾[1] 

机构地区：[1]郑州大学第一附属医院检验科,河南郑州450052 [2]郑州大学第一附属医院内科,河南郑州450052

出　　处：《中国现代医学杂志》2007年第23期2890-2893,2895,共5页China Journal of Modern Medicine

基　　金：河南省自然科学基金(No:0111023100)

摘　　要：目的探讨郑州地区汉族人群对氧磷酶2(paraoxonase 2,PON2)基因C311S多态性和2型糖尿病并发冠心病(DM-CHD)的关系。方法测定DM和DM-CHD患者外周血白细胞PON2基因C311S多态性及血清胆固醇、三酰甘油、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇等指标水平,进行分析研究。结果郑州地区汉族人群存在有PON2基因C311S多态性,DM-CHD组患者等位基因S频率大于DM组和对照组,在DM组和对照组间差异无显著性。DM-CHD和DM组内基因型SS患者仅HDL-C水平高于本组内基因型CC,其他脂类和脂蛋白指标差异均无显著性。结论郑州地区存在有PON2基因C311S多态性,并提示等位基因S可能是2型糖尿病并发冠心病的危险因素。[Obejctive] To investigate relationship between paraoxonase 2 （PON2） C311S gene polymorphism and patients with type Ⅱ diabetes mellitus （type 2 DM） complicated coronary artery diseases in Zhengzhou population of Han nationality. [Methods] PON2 C311S gene polymorphism was detected by PCR method, and serum cholesterol, triglyceride, high-density lipoprotein cholesterol （HDL-C） and so on were determined in patients with type Ⅱ diabetes mellitus （DM）, DM complicated with coronary artery disease （DM-CHD）, and healthy subjects. [Results] The PON2 C311S was found in Zhengzhou population of Han nationality. The S gene frequency in DM-CHD was higher than that in DM and healthy subjects. No significant difference between DM and control group, The level of HDLC in genotype SS with DM-CHD and DM groups were higher than that genotype CC in itself group only, [Conclusion] PON2 C311S pelymorphism was found in Zhengzhou Chinese population of Han nationality. It is suggested that S allele might be a risk factor for DM complicated CAD in Zhengzhou Chinese population of Han nationality.

关 键 词：糖尿病 冠心病 对氧磷酶 基因多态性 

分 类 号：R587.1[医药卫生—内分泌]