C反应蛋白水平在COPD病人、IHD病人,吸烟者和非吸烟者中的比较研究  

A comparative study on C-reactive protein among patients with COPD,IHD,smokers and nonsmokers

作　　者：刘漪[1] 戴路明[2] 丰继华[3] 张静珊[1] 和瑾[1] 张家骝[1] 

机构地区：[1]昆明市第一人民医院呼吸科,650011 [2]昆明医学院第一附属医院呼吸二科,650032 [3]中山大学电子通信工程系,生物信启方向510275

出　　处：《临床肺科杂志》2008年第1期13-15,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的评价在COPD病人中IHD症状和吸烟对CRP升高的潜在影响,并检验糖皮质激素(ICS)药物治疗与CRP血清水平之间的联系。方法对46名COPD患者与对照组的18名吸烟者(Smoking)和20名不吸烟者(N.Smoking)进行比较。结果COPD病人的CRP血清水平[4.83±1.23mg/L]显著高于两个对照组,具有显著性差异(P<0.05),但是CRP血清水平在两个对照组中却无统计学意义。ICS治疗后,COPD病人的CRP水平降低。结论对COPD病人使用ICS治疗能够降低CRP水平。CRP可以作为COPD患者体内组织炎症的标志物。Objective To evaluate IHD and smoking as potential causes of elevated CRP in COPD and to test the association between inhaled corticosteroids （ICS） use and serum CRP levels. Methods Cross-sectional analyses were conducted in comparing cohorts of 46 COPD patients with 18 smokers （S） and 20 non-smoker （NS） controls. Clinical assessments included a complete medical history, pulmonary function, 6-minute walking test （6MWT） and high-sensitivity serum CRP. Results Serum CRP levels were significantly higher in the COPD patients [ 4. 83 （1.23） mg/L] than in the controls（ P 〈 0.05 ） but were similar in both control groups [S： 2. 13 （1.06 mg/L） and NS： 2. 34 （1.04） mg/L]. CRP levels were lower in the COPD patients treated with ICS [ 3. 18 （2.7） mg/L vs 5.87 （2. 9） ]. Conclusion CRP levels were elevated in COPD patients without clinically relevant IHD, independent of cigarette smoking. CRP is reduced in COPD patients using ICS. We conclude that CRP may be a systemic marker of the inflammatory process that occurs in patients with COPD.

关 键 词：慢性阻塞性肺病 C反应蛋白 糖皮质激素 

分 类 号：R563.9[医药卫生—呼吸系统]