三维超声心动图测量左室心肌质量与心脏终点结局事件的相关性  

Correlation between left ventricular mass with three-dimensional echocardiography and cardiac endpoint events

作　　者：喻丽华[1] 蔡伟[1] 赵玉娟[1] 李学文[1] 

机构地区：[1]武警医学院附属医院心内科,天津市300162

出　　处：《中国组织工程研究与临床康复》2007年第48期9718-9721,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:为评价三维超声心动图在心血管疾病中的应用前景,验证左室心肌质量对心血管事件和死亡发生的预测价值,应用三维超声心动图检测左室心肌质量,探讨左室心肌质量与心血管病患者远期预后的关系。方法:①超声测定:选择2003-10/2007-04武警医学院附属医院CCU及普通病房住院的64例患者接受左室心肌质量指数、静息左室射血分数测定和NYHA心脏功能分级的评估,仪器采用彩色多普勒超声诊断仪,型号为GE vivid-7。②分组及随访:根据左室肥厚标准和各参数平均数分为2组,左室心肌质量指数男性<131g/m2或女性<100g/m2为Ⅰ组,男性≥131g/m2或女性≥100g/m2为Ⅱ组,连续随访54个月,观察终点为心源性死亡。结果:61例进入结果分析。随访期末发现左室心肌质量指数与远期死亡有着显著的相关性(r=0.592,P=0.000);静息左室射血分数和NYHA心脏功能分级与死亡没有相关性(P>0.05);左室肥厚的Ⅱ组死亡例数多于Ⅰ组(P<0.01),两组的静息左室射血分数和NYHA心脏功能分级比较差异不显著(P>0.05);左室心肌质量指数高于平均数的Ⅱ组与Ⅰ组死亡相对危险比为2.56(95%CI),差异有统计学意义(P=0.020),但是静息左室射血分数和NYHA心脏功能分级之间死亡相对危险比没有统计学意义(P>0.05)。结论:①左室心肌质量与心血管病患者远期预后关系密切,可用于预测心源性死亡的发生情况。②三维超声心动图测定左室心肌质量及功能参数方便准确,可用于心功能定量评估。AIM： To evaluate the prospect of applying three-dimensional echocardiography on cardiovascular disease, validate the value of left ventricular mass （LVM） on predicting cardiovascular incident and death, detect the LVM by using three-dimensional echocardiography, and explore the correlation between LVM and long-term prognosis for patients with cardiovascular disease. METHODS： （1）Sixty-four inpatients enrolled from Central Control Unit and Common Ward in the Affiliated Hospital of Chinese People＇s Armed Police Force Medical College between October 2003 and April 2007, they were assessed for left ventricular mass index （LVMI）, resting left ventricular ejection fraction （resting-LVEF） and New York Heart Association （NYHA） functional class. The apparatus adopted color Doppler ultrasound diagnosis analyzer （GE vivid-7）. （2）According to the diagnostic standard of left ventricular hypertrophy and the mean values of above parameters, the patients were divided into two groups： Ⅰ group： IVM1〈131 g/m^3 in males or 〈100 g/m^3 in females; Ⅱ group： LVMI≥ 131 g/m^3 in males or ≥ 100 g/m^3 in females. Endpoint was cardiogenic death, and each group was recorded during 54-month follow-ups. RESULTS： All the 61 subjects were involved in the result analysis. LVMI had a close correlation with long-term death （r =0.592, P =0.000）, but resting-LVEF and NYHA class had no correlation with death during the follow-up （P 〉 0.05）. There were more deaths in group Ⅱ compared with group Ⅰ （P 〈 0.01）, but there was no difference in resting-LVEF and NYHA class between the two groups （P〉 0.05）. The relative risk ratio of death （2.56, 95%CI） between the two groups with LVMI was above the mean values had significant differences （P =0.020）, but no significant difference between the two groups with the resting-LVEF and NYHA class was found （P 〉 0.05）. CONCLUSION： （1）LVM is closely related with the long-term prognosis of patients with cardiovascular diseas

关 键 词：彩色多普勒超声 左室心肌质量 左室心肌质量指数 长期预后 心源性死亡 

分 类 号：R318[医药卫生—生物医学工程]