壳聚糖的结构修饰及其应用(英文)  

Structural modification and application of chitosan

作　　者：张敏[1] 任慧霞[1] 

机构地区：[1]山东大学药学院生化与生物技术药物研究所,山东省济南市250012

出　　处：《中国组织工程研究与临床康复》2007年第48期9817-9820,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：学术背景:壳聚糖是甲壳素的衍生物,其水溶性较差,在很大程度上限制了它的应用。为了改善壳聚糖的溶解性,对其易于修饰的-OH和-NH2进行化学修饰,引入功能基团增加其溶解性和功能性,从而赋予了更多特殊的功能,潜在价值不断被发现,成为壳聚糖应用研究的新的发展方向之一。目的:通过检索文献对壳聚糖在羧基化、酰基化、烷基化、醚化等方面的修饰及其应用进行综述。检索策略:由该论文的研究人员应用计算机检索Pubmed 1998/2007的相关文献,检索词为"chitosan,modification"并限定语种为"English";应用计算机检索Elsevier Science 1998/2007中的相关文章,检索词为"chitosan,modification",二次检索"derivate"。对资料进行初审,纳入标准:与壳聚糖结构修饰及其应用相关的文章。排除标准:比较陈旧和重复性研究文章及综述。文献评价:共收集到154篇文章,30篇文献符合纳入标准,其中5篇为综述,其余均为临床或基础实验研究。资料综合:根据壳聚糖分子内的-OH和-NH2易于经行化学修饰的特点,多对这两个基团进行修饰。目前报道比较多的侧重于羧基化、酰基化、烷基化、醚化4个方面,通过引入功能性基团增加其水溶性和功能性,以达到拓宽其应用范围的目的。结论:通过对壳聚糖进行结构修饰,引入多功能基团,改善了其在水中的溶解性能,同时赋予了它更多的特殊功效。BACKGROUND：Chitosan, derived from chitin, has a poor solubility which limits its application greatly. For improving its dissolubility, according to the feature that intramolecular hydroxy and amino group in chitosan are easy to be chemically modified, and functional groups are introduced to improve its solubility and functionality to widen the range of its application, which has become one of the new trend of development for investigating the application of chitosan. OBJECTIVE： To sum up the research advancements in the application and modification of chitosan in carboxylation acylation, alkylation, etherification, etc. RETRIEVE STRATEGY： The relevant articles published in English between 1998 and 2007 were searched for in Pubmed database with the key words of ＂chitosan, modification＂, and the relevant articles published between 1998 and 2007 were searched for in Elsevier Science database with the key words ＂chitosan, modification＂ and search ＂derivate＂ within search results in English. Articles closely related to the structural modification and application of chitosan were involved, and repetitive and old studies were excluded. LITERATURE EVALUATION： Totally 154 articles were selected, and 30 of them are accorded with the inclusive criteria including 5 are reviews, and the others are clinical or experimental studies. DATA SYNTHESIS： The intremolecular hydroxy and amino groups in chitosan are mostly modified because they are easy to be chemically modified. Recently, reports lay particular emphasis on the modification in carboxylation, acylation, alkylation, etherification, etc. Functional groups are introduced to improve its solubility and functionality to widen the range of its application. CONCLUSION： The water-solubility of chitosan can be improved through structural modification and introducing multifunctJonal group, which can also bring about much more special efficacies.

关 键 词：壳聚糖 结构修饰 衍生物 羧基化、酰基化、烷基化、醚化 

分 类 号：R318[医药卫生—生物医学工程]