瑞芬太尼用于危重病人的镇痛与镇静  

Analgesic and sedative use of remifentanil in intensive care unit

作　　者：张艳[1] 皋源[1] 杭燕南[1] 

机构地区：[1]上海交通大学医学院附属仁济医院麻醉科外科重症监护室,上海200127

出　　处：《中国新药与临床杂志》2007年第12期939-942,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：瑞芬太尼是一种由酯酶代谢的强效μ阿片样受体激动剂,起效快、消除快,代谢不依赖于器官功能,用于外科重症监护室中气管插管机械通气病人或重症病人,能提供充分的镇痛并在此基础上保持病人镇静状态,减少麻醉性镇静药的使用,缩短呼吸机维持时间,促进拔管。本文综述危重病人中瑞芬太尼的药动学特点,及其在外科重症监护室的应用。Remifentanil is a neotype ultra-short-acting μ-opioid receptor agonist with unique properties such as organ-independent metabolism, lack of accumulation, rapid offset of action. Remifentanil provides analgesia and sedation for mechanically ventilated intensive care unit and critical ill patients, and can reduce the tendency of using anesthetic analgesic, decrease the duration of mechanical ventilation. In addition, remifentanil is generally well tolerated in this group of patients. This article comprehends pharmacokinetic properties and the analgesic and applications of remifentanil in the intensive care unit.

关 键 词：瑞芬太尼 呼吸 人工 镇痛 清醒镇静 

分 类 号：R971.2[医药卫生—药品]