同种异体骨与自体骨移植治疗青少年脊柱侧凸的比较研究  

Comparison of results between allograft and autograft for treatment of scoliosis in the adolescent

作　　者：田敏[1] 邹强[1] 孙磊[1] 张业峰[1] 宁廷民[1] 高加智[1] 马青元[1] 

机构地区：[1]解放军第88医院全军骨科中心,山东泰安271000

出　　处：《中国矫形外科杂志》2007年第23期1792-1794,共3页Orthopedic Journal of China

摘　　要：[目的]观察同种异体骨移植与自体骨移植治疗青少年脊柱侧凸的临床效果。[方法]对1996-2006年本科收治的63例青少年脊柱侧凸患者的临床资料,采用回顾性＂病例-对照＂研究方法进行分析,A组（同种异体骨移植组）32例,10-15岁,平均12.2岁;Cobb’s角38°-113°,平均62;°B组（自体髂骨移植组）31例,年龄9-14岁,平均12.4岁;Cobb’s角41°-105°,平均54°。所有患者均选择中华长城椎弓根内固定系统经后路矫正,术后定期随访并对临床效果进行评估。[结果]出院后2个月即开始随访,随访时间18-24个月,平均26个月;亦无严重并发症发生;A组的手术时间、失血量较B组患者减少,组间具有统计学意义（P〈0.01）。[结论]两组患者具有相似的临床效果,在严格掌握适应证,充分术前准备、正确手术操作、及时术后处理的前提下,同种异体骨移植能够有效替代自体髂骨移植治疗青少年脊柱侧凸。[Objective]To compare the clinical results between allograft and autograft for treatment of scoliosis in the adolescent.[Method]A retrospective study was made in 63 cases of adolescent patients with scoliosis who were operated on with posterior instrumentation from 1996-2006.These patients were divided into two groups.In group A,32 patients aged 10 to 15 years with an average of 12.2 years,had a mean Cobbs angle of 62°（ranged,38° to 113°）,were received allograft bone grafting.The patients were followed up for at least 18 months with an average of 26 months.Clinical and radiographic evaluations were performed.[Results]Operating time and blood loss in group A were less than that in group B（P〈0.01）.Solid bony fusion was achieved in all patients.The fusion rate and the loss of correction had no significant difference between the group A and the group B.[Conclusion]With proper indication,allograft could be a good alternative to autologous iliac bone for its safety,efficacy and reliability.

关 键 词：脊柱侧凸 脊柱融合术 骨移植 异体骨 

分 类 号：R687.3[医药卫生—骨科学]