参麦注射液治疗新生儿缺氧缺血性脑病的疗效观察  

Efficacy observation of Shenmai injection in treating neonatal hypoxic-ischemic encephalopathy

作　　者：王军[1] 蒋红侠 周长美[1] 杨丽娟[1] 张绍美[1] 

机构地区：[1]徐州医学院附属医院新生儿科,221002 [2]徐州市中心医院儿科

出　　处：《临床神经病学杂志》2007年第6期453-455,共3页Journal of Clinical Neurology

基　　金：江苏省卫生厅医学科技发展基金项目(Z200308);徐州市科学技术项目(200310)

摘　　要：目的探讨参麦注射液(SMI)治疗新生儿缺氧缺血性脑病(HIE)的疗效及其可能机制。方法将45例HIE的新生儿随机分为SMI治疗组和常规治疗组,SMI治疗组在常规治疗的基础上,应用SMI10ml加入10%葡萄糖溶液30～50ml中静脉滴注,每日1次,7～10d。观察两组症状改善情况及治疗后1d、3d、6d检测血酸性钙结合蛋白(S-100β)、神经元特异性烯醇化酶(NSE)水平变化;3月龄时进行神经精神运动评分,评价发育商(DQ)。结果SMI治疗组症状消失及平均住院时间较常规治疗组明显缩短(均P<0.01),治疗后3d、6d时SMI治疗组血清S-100β、NSE水平明显低于常规治疗组(均P<0.01)。3月龄时SMI治疗组DQ异常率(16.7%)明显低于常规治疗组(36.8%)(P<0.01)。结论SMI对新生儿HIE有较好的疗效。Objective To investigate the therapeutic effect of Shenmai injection （SMI）on neonatal hypoxicischemic encephalopathy （HIE） and it＇s possible mechanism. Methods 45 neonates with HIE were randomly divided into the SMI treatment group and routine treatment group. At the basic of routine treatment, the SMI ti＇eatment group was treated with 10 ml SMI added into 10% GS 30 - 50 ml via injecting into veins once a day for 7 - 10 d. The levels of serum S-IOOI3, NSE were measured at 1 d,3 d,6 d after treatment. The development quotients （DQ） was evaluated at 3-month-old infants. Results Compared with routine treatment group, symptoms of nervous system in SMI treatment group were recovered obviously faster, the hospitalization time was shorter （all P 〈0. 01 ）. The levels of serum S-IOOI3, NSE were obviously lower than those in routine treatment group at 3 d, 6 d after treatment （ all P 〈 0.01 ）. The rate of abnormity of DQ in SMI treatment group （ 16. 7% ） at 3-month was significantly lower than that in routine treatment group （36.8%） （ P 〈0. 01 ）. Conclusion There is better curative effect in SMI treated for neonate HIE.

关 键 词：缺氧缺血性脑病 参麦注射液 酸性钙结合蛋白 神经元特异性稀醇化酶 新生儿 

分 类 号：R272.1[医药卫生—中医儿科学]