苦苣提取物的心血管保护作用研究  

Effects of extract of Sonchus oleraceus on cardiovascular protection

作　　者：牟艳玲[1] 解砚英[1] 周玲[1] 徐淑兰[1] 胡志力[1] 王福文[1] 

机构地区：[1]山东省医学科学院药物所药理室山东省医用药物与技术重点实验室

出　　处：《中国临床药理学与治疗学》2007年第11期1241-1244,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：山东省自然基金青年基金项目(Q2005C07);山东省医学科学院院课题

摘　　要：目的:观察苦苣提取物的心血管保护作用。方法:采用常压耐缺氧、饥饿小鼠生存时间、急性心肌缺血模型、电刺激诱发血栓形成模型等实验方法,观察苦苣提取物的心血管药理活性。结果:苦苣提取物灌胃给药12.5g/kg和6.3g/kg均能明显增加小鼠常压下耐缺氧存活时间,能够延长饥饿小鼠的生存时间。3.2g/kg可明显降低大鼠血液黏度,延长大鼠体内血栓形成时间。苦苣提取物3.2g/kg和1.6g/kg对由垂体后叶素所致冠状动脉痉挛引起的大鼠急性心肌缺血具有明显的拮抗作用。结论:苦苣提取物具有活血化淤、抗心肌缺血的心血管保护作用。AIM： To observe the cardiovascular protective effects of extract from Sonchus oleraceus. METHODS： Several experiments including hypoxia experiment, the survival test of hungry mice, acute myocardial ischemia, and electrical stimulation of thrombosis model in rats were used to evaluate the pharmacy activity of extract of Sonchus oleraceus. RESULTS：Extract of Sonchus oleraceus markedly prolonged the living time of the fasting, hypoxia experimetal mice, the formation time of carotid artery thrombosis, decreased blood viscosity shear rate （compared with control, P 〈 0.01）, prevent myocardial ischemia caused by hypophysin. CONCLUSION： Extract of Sonchus oleraceus can prolong formation time of carotid artery thrombosis, anti-myocardial ischemia and then protect cardiovascular.

关 键 词：苦苣提取物 血液黏度 血栓形成 心肌缺血 生存时间 

分 类 号：R965.2[医药卫生—药理学]