人工合成胸腺素α1在猴体内静脉注射的药动学研究  

Pharmacokinetic study of synthesized thymosin alpha 1 in monkeys after intravenous administration

作　　者：王莉[1] 缪苗苗[1] 覃红[1] 吴勇杰[1] 崔明霞[1] 路莉[1] 

机构地区：[1]兰州大学药学院药理学研究所

出　　处：《中国临床药理学与治疗学》2007年第11期1274-1278,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:研究人工合成胸腺素α1(sTα1)在猴体内i.v.的血药浓度-时间曲线、药动学参数特点。方法:用竞争性ELISA法测定sTα1在猴体内i.v.后血清中的药物浓度,用DAS药动学统计软件进行血药浓度-时间曲线拟合及药动学参数计算。结果:猴i.v.sTα11.2mg/kg的药动学特征符合二室开放模型,呈一级动力学消除。结论:猴i.v.sTα1的药动学行为符合二室一级消除。AIM： To study pharmacokinetic property of synthesized thymosin alpha 1 （ sTα1 ） after intravenous （i. v. ） injection to monkeys. MIETHODS： Competition ELISA analysis was used for detecting drug concentration in sermn after i.v. administration of sTal in monkeys. Pharmacokinetic parameters were calculated by DAS software. RESULTS： Pharmacokinetic model of sTα1 after i.v. was consistent with two-compartment open model, and in accordance with first-order kinetic elimination. CONCLUSION： Pharmacokinetic model after i. v. of sTα1 is two-compaxtment open model, and in accordance with first-order kinetic elimination.

关 键 词：胸腺素 猴 药动学 酶联免疫吸附测定 

分 类 号：R969.1[医药卫生—药理学]