替加色罗片对慢性便秘患者的消化不良症状、胃电活动、胃肠传输和肛管直肠功能的影响  

Effects of tegaserod on dyspeptic symptoms, electrogastrography, gastrointestinal transit and anorectal function in chronic constipation

作　　者：李翠萍[1] 刘诗[1] 谢小平[1] 侯晓华[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院消化内科

出　　处：《中国临床药理学与治疗学》2007年第11期1311-1316,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:研究口服替加色罗对慢性便秘患者伴随的消化不良症状、胃电活动、胃肠传输和肛管直肠功能的影响。方法:43例慢性便秘患者进行口服4周替加色罗6mg每日两次或安慰剂随机双盲治疗。治疗前后用消化不良症状问卷、不透X线标记物法、胃电图和直肠肛管测压法评估患者消化不良症状、胃电活动、胃肠传输和肛管直肠功能的变化。结果:与安慰剂组相比,替加色罗组慢性便秘患者伴随的消化不良症状总积分治疗后较治疗前显著降低(11.57±3.24vs5.29±1.18,P=0.024)。替加色罗组治疗后空腹-餐后胃电正常节律百分比变化较治疗前显著减小(6.58%±1.29%vs11.80%±3.85%,P=0.044)。替加色罗组患者胃内残余钡条数较治疗前显著减少(5.95±1.65vs4.57±1.65,P=0.036);结肠内残余标记物数量(7.50±2.02vs5.89±1.94,P=0.029)较治疗前显著减少,其中右半结肠(1.06±0.50vs0.67±0.23,P=0.035)和直肠乙状结肠(3.33±1.28vs1.50±1.01,P=0.017)残余标记物数显著减少。替加色罗治疗后直肠排便窘迫阈值[(25.2±1.8)mmHgvs(22.9±2.0)mmHg,P=0.028,1mmHg=0.133kPa]和最大容量感觉阈值[(32.1±2.5)mmHgvs(29.3±2.3)mmHg,P=0.043]显著降低。替加色罗治疗后初次排便感觉阈值和肛管直肠压力较治疗前无统计学差异(P>0.05)。结论:替加色罗能改善慢性便秘患者的消化不良症状,改善餐后胃电活动,加速胃肠传输,降低直肠感觉阈值,提高直肠敏感性。AIM： To assessment the effects of tegaserod 6 nag Bid on dyspeptic symptoms, electrogastrography, gastrointestinal transit and anorectal function in chronic constipation （CC）. METHODS： The study consisted of a 2-week baseline period, a 4-week randomized, double-blind treatment period with tegaserod 6 mg Bid or placebo. The treatment was conducted in 43 patients with CC and symptoms of dyspepsia. Dyspeptic symptoms, gastric myoelectrical activity, gastrointestinal transit and anorectal function were evaluated before and after treatment of tegaserod or placebo.RESULTS： In comparison with placebo, ①total dyspeptic symptom scores in patients of CC treated with tegaserod 6mg Bid for 4 weeks were lower than before（ 11.57 ± 3.24 vs 5.29± 1.18, P = 0.024） ;②Tegasered decreased normal percentages of postprandial electrogastmactivity （6.58%± 1.29% vs 11.80% ±3.85%, P = 0.044） ; ③Tegaserod 6 mg Bid significantly accelerated markers in stomach （5.95 ± 1.65 vs 4.57 ± 1.65, P = 0.036） and decreaseu those in the colon（7.50±2.02 vs 5.89± 1.94,P =0.029）; ④Tegaserod 6 nag Bid significandy decreased the sensation of defecation volume [（25.2± 1.8） mm Hg vs （22.9 ± 2.0） mm Hg, P = 0.028 ] and maximal tolerable volume [（32.1±2.5） mmHgvs （29.3±2.3） mm Hg, P = 0.043]; ⑤ There was no significant difference in Me first sensation volume, rectal resting pressure, anal resting pressure and maximal squeezing pressure after tegaserod treatment （ P 〉 0.05）. CONCLUSION： Tegaserod 6 mg Bid for 4 weeks may relieve dyspeptic symptoms, significantly accelerate gastrointestinal transit and improve postprandial electrogastroactivity, and decrease the sensation of defecation volume and maximal tolerable volume in patients with with CC.

关 键 词：替加色罗 慢性功能性便秘 消化不良症状 胃电活动 胃肠传输 直肠肛管测压 

分 类 号：R969[医药卫生—药理学]