一类环丙烷螺环化合物的简易合成和结构表征  

Synthesis and Structure Elucidation of a Series of Spiro Cyclopropane Derivative

作　　者：施志坚[1] 刘卫霞[1] 曹卫国[1] 赵杨[1] 张顺利[1] 刘梅[1] 

机构地区：[1]上海大学化学系

出　　处：《分析化学》2007年第12期1779-1782,共4页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金资助项目(No.20472047)

摘　　要：以乙二醇二甲醚为溶剂,在K2CO3及痕量水存在下,鉮盐和多取代贫电子烯烃反应,高立体选择性合成了顺-1-甲氧羰基-2-取代芳基-6-环己烷基-5,7-二氧杂螺-〔2,3〕-4,8-二酮。采用IR、MS、1H NMR、13C NMR、DEPT及二维核磁共振技术对所合成的化合物进行了结构表征,并以NOESY实验确定了该化合物为顺式结构的环丙烷衍生物。A series of electron-deficient olefins were synthesized. In the presence of K2CO3 and trace water in diethunol dimethyl ethene, these olefins react with arsenic ylide to give electron-deficient cyclopropane derivatives with high stereoselectivity. The structure of these new compounds were charactered by ^1H NMR, ^13C NMR, infrared and mass spectrometry. In the same time the stereoconfiguration of the compound Ⅶ was confirmed by nuclear overhauser effect spectroscopy.

关 键 词：核磁共振 结构表征 二维核磁共振谱 环丙烷衍生物 

分 类 号：O621.2[理学—有机化学]