磁共振动态磷谱对正常人骨骼肌运动状态功能的定量研究  

The Quantitative Study of Skeletal Muscle Function During Exercise Using Dynamic Phosphorus Magnetic Resonance Spectroscopy

作　　者：齐静[1] 王德杭[1] 徐青[1] 吴飞云[1] 

机构地区：[1]南京医科大学第一附属医院放射科,210029

出　　处：《临床放射学杂志》2007年第12期1247-1251,共5页Journal of Clinical Radiology

基　　金：江苏省自然科学基金资助项目(编号:BK2006578)

摘　　要：目的用磁共振动态磷谱技术(31P-MRS)无创性在体评价骨骼肌的功能。资料与方法对10名成年人和6名青少年受试者骨骼肌进行动态31P-MRS分析,对磷酸单酯(PME)、无机磷(Pi)、磷酸二酯(PDE)、磷酸肌酸(CP)、γ-ATP、α-ATP和β-ATP进行半绝对定量分析,同时计算二磷酸腺苷(ADP)和线粒体内氧化磷酸化潜能(PP)以及细胞内镁离子的浓度。分析在静息期、运动期和恢复期两组受试者能量代谢特点及肌肉做功效率。结果肌肉运动时CP和PP含量明显降低,Pi、Pi/CP和ADP升高,而ATP维持恒定。青少年肌细胞内ATP明显高于成人,而CP和PP含量相似,动态变化趋势相同。成人做功较多,但肌肉的效率与青少年组相同。结论动态磷谱技术可以无创性定量评价骨骼肌不同运动状态能量代谢特点,为肌肉的功能影像学提供客观信息。Objective To evaluate skeletal muscle function using in vivo dynamic Phosphorus Magnetic Resonance Spectroscopy （^31P-MRS）. Materials and Methods Noninvasive ^31P-MRS was acquired from quadriceps muscles of 10 adults and 6 juvenile subjects during rest, exercise and recovery periods. The absolute concentration of PME, Pi, PDE, CP, and ATP were determined from spectra, and the value of ADP, phosphorylation potential （PP）, and enzymatically active Mg-ATP complex were calculated. The work/cost ratios were derived from weight/（Pi/CP） to compare muscle efficiency between adults and young subjects. Results During exercise, CP and PP concentration decreased, Pi, PI/CP and ADP values increased. The levels of ATP and Mg-ATP, on the other hand, remained constant. Juvenile subjects shared the same dynamic pattern as adults. CP and PP concentration were similar in both group, and there was no difference in workhag efficiency. However, young subjects had lower PDE compounds and higher ATP, Mg ATP and total Mg levels. Conclusion Dynamic 31 P-MRS can reflect energy metabolism of skeletal muscle during exercise and provides valuable information to evaluate muscle functional imaging.

关 键 词：磁共振磷谱 功能影像学 骨骼肌 运动 

分 类 号：R445.2[医药卫生—影像医学与核医学]