复智散对阿尔茨海默病患者事件相关诱发电位的影响  

Effects of Chinese compound Fuzhisan on the event related potential in patients with Alzheimer's disease

作　　者：刚宝芝[1] 沈翠茹[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院神经内科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2007年第6期581-583,共3页Journal of Harbin Medical University

基　　金：国家自然基金项目(30670726);黑龙江省自然基金重点项目(ZJY03-5)

摘　　要：目的探讨中药复智散对阿尔茨海默病(Alzheimer’s disease,AD)患者事件相关诱发电位(event related poti-ential,ERP)影响。方法AD组40例,分复智散组(n=24)和安理申组(n=16),规范治疗40d,对照组为30例健康老人,治疗前后进行ERP检测和简易智力状态(MMSE)评定,探讨事件相关诱发电位与MMSE的相关性。结果与对照组比较,AD患者靶刺激P2、N2、P3的潜伏期明显延长(P<0.01),P2、P3波幅降低(P<0.01),复智散治疗后P2、N2、P3潜伏期明显缩短,P2、P3波幅明显提高,与安理申组比较潜伏期缩短但没有显著差异(P>0.05),P3波幅提高优于安理申组(P<0.05)。MMSR评分与ERP部分靶刺激潜伏期呈负相关,而与靶刺激的波幅呈正相关。结论复智散能缩短AD患者ERP的潜伏期和提高ERP的波幅。Objective To study effects of Chinese compound Fuzhisan on the event related potential in patients with Alzheimer＇s disease.Methods Fourty patients with Alzheimer＇s disease were randomly divided into FZS group（ n = 24）and donepezil group（ n = 16）. Thirty healthy elder people were served as the controls. ERP was tested at the beginning and at the end of 40 days, and scores of MMSE assessed meanwhile. Results Compared with control group,the patients with AD group showed delayed latency of target P2,N2 and P3,decreased amplitudes of target P2 and P3. The latency of target P2, N2 and P3 were shortened, differences between FZS groups and donepzeil group were not signicifient（ P 〉 0.05）,and the amplitudes of target P2 and P3 were increased after the treatment. FZS group was better than donepezil group in improving amplitudes of target P3. The score of MMSE was negatively correlated with the latency of partial target stimulation, but positively with the amplitudes. Conclusion FZS can decrease ERP latencies and elevate ERP amplitudes in Alzheimer＇s disease.

关 键 词：事件相关电位 阿尔茨海默病 复智散 安理申 

分 类 号：R287.1[医药卫生—中药学] R741.044[医药卫生—中医学]