Vitellogenic responses of male Chinese loach (Misgurnus anguillicaudatus) exposed to the individual or binary mixtures of 17β-estradiol and nonylphenol  

作　　者：LU XueFei ZHOU QunFang SONG MaoYong JIANG GuiBin SHAO Jing 

机构地区：[1]State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Beijing100085, China

出　　处：《Chinese Science Bulletin》2007年第24期3333-3338,共6页

基　　金：Supported by the State High Tech Development Plan (Grant No. 2006AA06Z424);National Basic Research Program of China (Grant No. 2003CB415001); National Natural Science Foundation of China (Grant No. 40503014);Chinese Academy of Sciences (Grant No. KZCX3-SW-431)

摘　　要：Male Chinese loaches were exposed to 17β-estradiol (E2) and nonylphenol (NP) both singly and in combination for 42 days using semi-static waterborne exposure system. Plasma vitellogenin (Vtg) was chosen as determining endpoint. The results demonstrated that 0.5 μg/L E2 could induce the enhancement of Vtg contents in male Chinese loaches after exposure for 21 days, which showed a time-related increasing manner; NP was also estrogenic to male Chinese loach, and the vitellogenic responses showed in a time-and dose-related manner, which was less potent than that of E2. The bi- nary mixtures of E2 and NP can significantly elicit the production of Vtg in male Chinese loaches, which was more potent than that of individual compounds, and Vtg induced in the binary mixture groups was higher than the summation of Vtg induced in the corresponding single-compound groups at the same concentration.Male Chinese loaches were exposed to 17β-estradiol （E2） and nonylphenol （NP） both singly and in combination for 42 days using semi-static waterborne exposure system. Plasma vitellogenin （Vtg） was chosen as determining endpoint. The results demonstrated that 0.5 μg/L E2 could induce the enhancement of Vtg contents in male Chinese loaches after exposure for 21 days, which showed a time-related increasing manner; NP was also estrogenic to male Chinese loach, and the vitellogenic responses showed in a time- and dose-related manner, which was less potent than that of E2. The binary mixtures of E2 and NP can significantly elicit the production of Vtg in male Chinese loaches, which was more potent than that of individual compounds, and Vtg induced in the binary mixture groups was higher than the summation of Vtg induced in the corresponding single-compound groups at the same concentration.

关 键 词：化学相互作用 内分泌 17Β-雌二醇 卵黄蛋白原 

分 类 号：Q501[生物学—生物化学]