乙肝病毒P基因区YMDD变异的临床检测技术进展  

Progress of clinical technologies to detect YMDD mutation of hepatitis B virus

作　　者：信芝[1] 宋家武[1] 

机构地区：[1]中山大学附属第五医院消化内科,广东珠海519000

出　　处：《世界感染杂志》2007年第6期456-460,共5页World Journal of Infection

摘　　要：核苷类药物治疗乙型肝炎疗效确切，长期使用常导致病毒发生耐药性突变，其耐药的产生主要集中于HBVP基因的YMDD基序，耐药株的出现不仅会影响药物效果，引起病毒反跳，还易诱发机体新的免疫攻击，甚至导致严重后果。其临床检测具有重大的指导治疗和预测疾病预后的临床价值，因此，对YMDD变异的检测成为当今研究的热点之一。为此，我们对目前临床上常用的或具有很好临床应用前景的YMDD变异的检测技术及主要进展作一综述。The nucleoside analogue has been used widely as an effective antiviral agent for the treatment of patients with chronic hepatitis B virus （HBV） infection. However, mutations resistant to lamivudine occur very frequently after long-term therapy, especially in the tyrosine-methionine-aspartate （YMDD） motif of HBV polymerase. Mutations will not only decrease the sensitivity to lamivudine and cause virus rebound, but also induce new immune attack of the body even result in serious consequences. Detection of YMDD motif variants has been one of the focuses of clinical study because of its important value to guide treatment and appraise prognosis. In this work, we sum up the YMDD detection technologies and its progression that are used widely in clinic or having good prospect.

关 键 词：乙肝病毒 YMDD变异 临床检测 

分 类 号：R512.62[医药卫生—内科学] R373.21[医药卫生—临床医学]