齐多夫定引起心肌病的诊断（附1例临床分析）  

Diagnosis of myocardiopathy caused by 3-azido-3-deoxythymidine and one case of clinical analysis

作　　者：张宏伟[1] 马小军[3] 张彤[1] 张立[2] 周枫[2] 朱红[2] 王小兵 李太生[3] 曹韵贞[2] Jiao Jin Hua Chamberlin Judith Chen Ray Pettinelli Carla 

机构地区：[1]首都医科大学附属北京佑安医院感染科,北京100069 [2]中国医学科学院艾滋病研究中心,北京100730 [3]中国医学科学院北京协和医院感染科,北京100730 [4]山西省闻喜县人民医院,山西闻喜043800 [5]Westat,lnc USA [6]NIH,DAIDS,USA

出　　处：《世界感染杂志》2007年第6期480-482,共3页World Journal of Infection

基　　金：中国艾滋病综合性研究项目（CIPA）（编号：U19A151915-04）

摘　　要：目的为了提高艾滋病抗病毒治疗过程中罕见病例的诊断水平，本文分析了齐多夫定（AZT）所致心肌病的临床和实验室检查特点。方法介绍并讨论1例病人的病情发展及诊治经过，探讨AZT所致心肌病的发生机制。结果病人出现心衰症状，影像学检查见扩张性心肌病表现，综合分析认为，心肌病由AZT导致。结论AZT是引起扩张性心肌病的药物之一，尽管这一不良反应的发生较为罕见，但在临床工作中也应警惕。Objective To improve diagnostic level of rare cases during antiretroviral therapy, we analyze the clinical and laboratory characters of dilated cardiomyopathy caused by AZT. Methods We described development of the disease and process of the diagnosis, analyzed mechanism of cardiomyopathy caused by AZT. Results The patient had heart failure symptoms. Imagine examinations showed findings of dilated cardiomyopathy. The myocardiopahy of this patient was caused by AZT. Conclusions AZT is a kind of drugs which can cause myocardiopathy. Though this adverse event is rare, we should keep an eye out for it.

关 键 词：艾滋病 抗病毒治疗 心肌病 

分 类 号：R542.2[医药卫生—心血管疾病]