养血清脑颗粒治疗老年慢性脑供血不足患者临床研究  

Clinical study of Yangxue Qingnao Granule in treating Chronic Cerebral Circulation Insufficiency in elderly patients

作　　者：康建强[1] 刘蓓菁[1] 

机构地区：[1]上海交通大学医学院附属新华医院老年科,200092

出　　处：《老年医学与保健》2007年第6期366-368,共3页Geriatrics & Health Care

摘　　要：目的观察养血清脑颗粒治疗慢性脑供血不足患者的临床疗效并探讨其治疗机制。方法将80例慢性脑供血不足患者随机分为两组:治疗组用养血清脑颗粒,对照组用尼莫地平片,两组均静滴能量合剂+拜阿斯匹林,疗程4周。观察疗效及治疗前后血浆一氧化氮(NO)和内皮素(ET-1)水平的变化。结果养血清脑颗粒能显著改善慢性脑供血不足患者的临床症状,治疗后两组比较差异有统计学意义(P<0.05);治疗前后比较NO和ET-1水平:治疗组血浆NO增高(P<0.01),ET-1水平下降(P<0.01),与对照组相比,差异有统计学意义(P<0.01)。结论养血清脑颗粒治疗慢性脑供血不足有较好疗效,调控血管活性物质是其作用的关键。Objective To investigate therapeutic efficacy and mechanisms of Yangxue Qingnao Granule on the treatment of chronic cerebral circulation insufficiency （CCCI）. Methods 80 CCCI patients were equally randomized to two groups： the study group using Yangxue Qingnao Granule, and the control group using Nimodipine Tablet. Patients in both groups were additionally administered with Asprin and ATP, CoA and other energy mixture agents. The eurative effects were observed after 4-week treatment. Plasma nitric oxide （NO） and endothelin （ET-1） were measured before and after treatment in all patients. Results There was significant difference in curative effects between the study group. Yangxue Qingnao Granule improved the clinical symptoms of the patients significantly better than Nimodipine （P〈0.05）. Plasma NO level increased significantly and ET-1 decreased significantly in the study group as compared with the control group （both P〈0.01）. Conclusions Yangxue Qingnao Granule has better curative effects for CCCI, and the action mechanism is probably by re,dating secretion of VASOactive substances.

关 键 词：脑缺血 养血清脑颗粒 一氧化氮 内皮缩血管肽类 老年人 

分 类 号：R277.7[医药卫生—中医学]