武汉地区人群高尿酸血症与代谢综合征的相关性  

Relationship between hyperuricemia and metabolic syndrome in a population of Wuhan area

作　　者：刘佩文[1] 陈璐璐[2] 孙晖[2] 周瑞[1] 马杰[1] 张红梅[1] 周约伟[1] 陶燕[1] 易兰兰[1] 王望东[1] 曾庆玲[1] 

机构地区：[1]湖北省新华医院,武汉430015 [2]华中科技大学同济医学院附属协和医院

出　　处：《中国糖尿病杂志》2007年第12期727-728,共2页Chinese Journal of Diabetes

基　　金：中央保健委员会重点科研基金资助项目(鄂B044);湖北省科委科技计划课题资助项目(2001AA307B21)

摘　　要：目的探讨高尿酸血症与代谢综合征的关系。方法对1278名健康体检者进行高尿酸血症与代谢综合征各项指标患病率统计,血尿酸(SUA)与代谢综合征各项指标的相关分析,SUA与HO-MA-IR的多元回归分析。结果(1)高尿酸血症组中肥胖、高腰臀比、IFG、高TC、高TG、高血压病的发生率均比正常尿酸组显著增多(P<0.05);(2)SUA与HOMA-IR呈正相关;(3)代谢综合征组高尿酸血症患病率为22.76%,显著高于正常人群组的患病率11.34%(P<0.001)。结论高尿酸血症可能是代谢综合征发生发展的重要因素。Objective To evaluate a possible relationship between hyperuricemia （HUA） and metabolic syndrome （MS）. Methods The prevalence rates of UA and MS were calculated and analyzed in 1278 persons who underwent health check up. Analysis was carried out on the blood uric acid and parameters of MS, and a multiple regression analysis was performed on blood uric acid and HOMA-IR. Results （1） The prevalences of obesity,high WHR, high IFG, HBP, HTG, HTC were significantly higher in high uric acid group that in normal uric acid group. （2）The blood uric acid was positively correlated with HOMA-IR. （3） The prevalence of high uric acid in MS group was significantly higher than that in the group without MS. Conclusion High uric acid level may be an important factor for development and progress of MS.

关 键 词：高尿酸血症 代谢综合征 患病率 

分 类 号：R589[医药卫生—内分泌]