福辛普利对糖尿病肾病大鼠肾小管间质的影响  

The effects of fosinopril treatment on the renal tubulointerstitium in rat diabetic nephropathy

作　　者：冯梅[1] 黄颂敏[2] 张翥[3] 付平[2] 周莉[2] 

机构地区：[1]四川省肿瘤医院肿瘤内科,成都610041 [2]四川大学华西医院肾脏内科 [3]河南中医学院附一院肾脏内科

出　　处：《中国糖尿病杂志》2007年第12期763-765,共3页Chinese Journal of Diabetes

摘　　要：目的观察福辛普利对糖尿病肾病大鼠Cubilin、结缔组织生长因子(CTGF)和α平滑肌抗体(α-SMA)的影响。方法将SD大鼠随机分为糖尿病肾病(DN)组(n=9)、福辛普利治疗(DN-F)组(n=8)和正常对照(NC)组(n=6);检测各组大鼠第6周Cubilin、CTGF和α-SMA的水平。结果与DN组相比,DN-F组的Cubilin显著升高,CTGF和α-SMA明显降低(P<0.05)。结论福辛普利能显著提高DN大鼠Cubilin的表达,降低CTGF和α-SMA的表达,延缓肾脏纤维化。Objective To observe the effect of fosinopril on the expressions of the cubilin,CTGF and α-SMA in the STZ-induced diabetic rats. Method SD rats were randomly allocated into diabetic nephropathy（DN） ,fosinopril-treated DN（DN-F） and NC groups. We measured the biochemical indexes, determined the expression levels of the cubilin, CTGF and α-SMA. Results Compared with the DN group, the cubilin was significantly increased, and the CTGF and α-SMA were decreased （P〈0. 05）in DN-F group. Conclusion Fosinopril can increase the expression of cubilin, decrease the expressions of CTGF and α-SMA, which may associate with delaying the development of the renal tubulointerstitial fibrosis.

关 键 词：糖尿病肾病 肾小管间质 CUBILIN 

分 类 号：R692[医药卫生—泌尿科学]