血清白细胞介素-18和基质金属蛋白酶-2对急性冠脉综合征的临床意义  

Measurement of serum interleukin-18 and matrix metalloprotein -2 in the patients with acute coronary syndrome and its clinical significance

作　　者：崔艳[1] 邓丽华[1] 白露[2] 张春玲[1] 王悦彤[1] 臧晓凤[1] 

机构地区：[1]哈尔滨市第一医院心内科,150010 [2]哈尔滨医科大学第二临床医学院,150086

出　　处：《中国急救医学》2007年第12期1117-1119,共3页Chinese Journal of Critical Care Medicine

摘　　要：目的探讨血清白细胞介素-18(IL-18)、基质金属蛋白酶-2(MMP-2)的检测与冠状动脉病变的关系。方法采用双抗体夹心ELISA法测定66例冠状动脉造影证实至少有1支以上冠状动脉狭窄≥50%的冠心病患者和14例经冠状动脉造影排除冠心病患者的血清IL-18、MMP-2水平。结果血清IL-18、MMP-2水平在急性冠状动脉综合征的患者中明显增高,与正常组和稳定型心绞痛组间差异有统计学意义(P<0.01);双支和三支血管病变患者血清IL-18、MMP-2水平高于正常对照组,组间比较差异有统计学意义(P<0.05)。结论检测血清IL-18、MMP-2对急性冠脉综合征有重要临床价值。Objective To investigate the correlation between serum level of interleukin （IL） - 18 and matrix metalloprotein （ MMP） -2 and the severity of coronary artery stenosis in the patients with coronary heart disease（ CHD） . Methods Serum IL- 18 and MMP- 2 levels of 66 cases with CHD and 14 cases of normal controls were determined by enzyme - linked immunosorbent assay（ ELISA）. Results Serum level of MMP- 2 and IL- 18 were significantly high in acute coronary syndrome patients, there was significant difference between stable angina pectoris and normal controls;Among CHD group, patients with stenosis lesion in 2 or 3 branches of coronary artery had higher MMP - 2 and IL - 18 level, and serum MMP -2 and IL - 18 concentration were positively correlated with the severity of coronary artery stenosis. Conclusion IL- 18 and MMP- 2 could be used as valuable parameters for coronary artery disease.

关 键 词：白细胞介素-18 基质金属蛋白酶-2 急性冠脉综合征 心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]