GC-TOF-MS技术快速鉴定抗风湿痛胶囊中添加的西药成分  

Rapid Determination of the Unknown Chemical Medicine by Gas Chromatography Time of Flight Mass Spectrometry

作　　者：吴胜明[1] 董标[1] 王娜[1] 李昱[1] 梁月琴[1] 董方霆[1] 张学敏[1] 

机构地区：[1]国家生物医学分析中心,北京100850

出　　处：《质谱学报》2007年第4期214-218,共5页Journal of Chinese Mass Spectrometry Society

摘　　要：应用高分辨GC-TOF-MS对抗风湿痛胶囊中的未知西药成分进行快速鉴定。使用不同极性的有机溶剂进行提取,将提取物分别离心,取上清液进行气质联用分析,并借助Nist2002数据库进行鉴定,用精确分子质量和元素分析进行确证。分析发现,此抗风湿痛胶囊中添加了甲氧苄氨嘧啶、磺胺甲恶唑、安定、可待因、茶碱等5种西药。用液质联用仪对甲氧苄氨嘧啶、磺胺甲恶唑进行了定量分析。该方法可用于未知混合物的分析,同样适用于中药制剂中其他西药成分的快速检出。The unknown chemical medicine in antirheumatism ly by gas chromatography-time of flight mass spectrom the capsules with different polar organic solvent was etry analy capsules was determined rapid（GC-TOF-MS）. Extraction of zed by GC-TOF-MS. The ob- tained pseudomolecular ions, fragment ions and accurate mass were used to identify the adulterated chemical medicine by the database Nist 2002. The result indicates that five drugs （theophylline, codeine, diazepam, trimethoprim, sulfamethoxazole） are illegally adulterated in the antirheumatism capsules. This method is rapidly and sensitively, which can be used to analyze the unknown mixture and the adulterated chemical medicine in hygienical foods.

关 键 词：GC-TOF-MS 快速鉴定 抗风湿胶囊 西药成分 

分 类 号：O657.63[理学—分析化学]