AC960对微管蛋白聚合—解聚活性的影响  

Effect of AC960 on Polymeric-depolymeric Activity of Microtubulin

作　　者：王昌俊[1] 陈伟[1] 胡月娟[1] 钱伯文[1] 

机构地区：[1]上海中医药大学,上海200032

出　　处：《南京中医药大学学报》1997年第5期275-276,共2页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：上海市教委资助

摘　　要：通过动物实验．观察AC960对微管蛋白聚合—解聚活性的影响。结果显示：AC960能明显抑制微管蛋白聚合，其作用略弱于秋水仙碱，且同时有抑制微管蛋白解聚作用。说明AC960抗癌机理可能在于影响微管蛋白的聚会—解聚活性，破坏纺缍丝形成，从而抑制癌细胞有丝分裂，促进其凋亡。The effect of AC960 was observd on polymeric-depolymeric activity of microtubulin in an ani-mal experiment. The result showed that AC960 could markedly inhibit the polymeric-depolymeric activity,which indicated that its anti-cancer effect was related to this inhibition and the prevention of the formation ofspindle fibers, thus inhibiting the mitosis of cancer cells.

关 键 词：微管蛋白 聚合 解聚 AC960 

分 类 号：R289.5[医药卫生—方剂学]