蚁王胶囊对大鼠的长期毒性实验研究  

Study on the chronic toxicity of YiWang Capsule in rats

作　　者：房志仲[1] 李晓华[1] 吕菁菁[1] 杨金荣[1] 

机构地区：[1]天津医科大学药学院药剂学教研室,天津300070

出　　处：《天津医科大学学报》2007年第4期504-506,510,共4页Journal of Tianjin Medical University

摘　　要：目的:观察蚁王胶囊对大鼠有无长期毒性。方法:将蚁王胶囊原粉配成混悬液,分别以0.28 g/(kg.d)和0.85 g/(kg.d)的剂量给予大鼠灌胃,每周7 d,连续3个月,观察大鼠的血液学指标(包括凝血时间、红细胞、白细胞、血小板计数、白细胞分类和血红蛋白含量),尿常规,血液生化指标(GOT、GPT、BUN、肌酐、总胆固醇含量)及各脏器(心、肝、脾、肺、肾、肾上腺、甲状腺、睾丸或卵巢)情况并进行组织病理学检查。结果:与空白对照组相比,两剂量蚁王胶囊对大鼠体重增长和一般行为活动无明显影响;两组大鼠的血液学、尿常规及血液生化学等指标无明显变化。给药组大鼠各主要脏器指数均与对照组动物无明显差异。组织病理学检查结果显示各组动物主要脏器均无毒性病理性改变。结论:蚁王胶囊以相当于临床用量30倍的剂量给予大鼠口服灌胃3个月,未产生明显毒性反应。Objective： To observe the chronic toxicity of YiWang Capsule. Methods： 80 rats were divided into 3 groups given YiWang Capsule in dose of 0.28 g（kg·d）（1 ml/100 g）, 0.85 g/（kg.d）（1 ml/100g） in 90 days continuously. Indexes were observed, including hematological indexes （Coagulation time, RBC, WBC, count of platelet, classification of WBC and hemoglobin）, biochemical indexes in blood （GOT, GPT, BUN,Cr,Tch）, organ/body weight ratio （ heart, liver, spleen, lung, kidney ,adrenal gland, thyroid, testis and were examined and showing no significant differences. Conclusion： Rats given YiWang Capsule in doses of 30 times of human dose for 90 days continuously have no toxic reaction.

关 键 词：蚁王胶囊 长期毒性 大鼠 

分 类 号：R96[医药卫生—药理学]