2型糖尿病合并脑梗死患者血浆t-PA、PAI含量变化及临床分析  

The relationship of the content of plasma t-PA、PA I and complication with cerebral infarction in patients with type 2 diabetes

作　　者：郭金玲[1] 张连凤[2] 王金良[2] 

机构地区：[1]天津市公安医院内科,天津300052 [2]天津市公安医院检验科,天津300052

出　　处：《天津医科大学学报》2007年第4期581-582,585,共3页Journal of Tianjin Medical University

摘　　要：目的:探讨2型糖尿病患者与2型糖尿病合并脑梗死患者血浆t-PA、PAⅠ水平变化及相关性。方法:检测2型糖尿病患者49例与2型糖尿病合并脑梗死患者51例的血浆纤溶酶原激活物(t-PA)、纤溶酶原激活抑制剂-1(PAⅠ)、空腹血糖(FBG)、甘油三脂(TG)含量及体重指数(BMI),用统计学方法进行相关性分析;设30例正常人为对照组。结果:2型糖尿病患者与2型糖尿病合并脑梗死患者的血浆t-PA含量均明显降低,而血浆PAⅠ、FBG和TG含量升高,与正常对照组有显著差异(P<0.05);而2型糖尿病合并脑梗死患者的血浆t-PA含量低于不合并脑梗死的2型糖尿病患者,且PAⅠ、FBG和TG含量升高,两组比较有显著性差异(P<0.05)。结论:2型糖尿病患者并发脑梗死与血浆t-PA、PAⅠ含量的失衡有关。Objective： To study the relationship of the content of plasma t-PA, PAI and complication with cerebral infarction in patients with type 2 diabetes. Methods： The plasma of t-PA,TG, FBG were measured in 49 patients with type 2 diabetes, 51 patients with type 2 diabetes complicated with cerebral infarction and 30 normal subjects. Results： The content of plasma t-PA were significantly lower and PA Ⅰ FBG,TG were significantly higher in type 2 diabetes and type 2 diabetes with cerebral infarction than those in normal group （P〈0.05）;the content of plasma t-PA were significantly lower and PA Ⅰ, FBG, TG were higher in type 2 diabetes with cerebral infarction than those in type 2 diabetes without cerebral infarction （P〈0.05）. Conclusion： The unbalance of content of t-PA and PAⅠ may associate with complication of cerebral infarction in patients with type 2 diabetes.

关 键 词：2型糖尿病 脑梗死 血浆t—PA 血浆PA Ⅰ 

分 类 号：R587.1[医药卫生—内分泌]