血吸虫病DNA疫苗联合免疫研究进展  

Progress on combined immunization with schistosomiasis DNA vaccines

作　　者：郑辉[1,2] 沈继龙[1] 

机构地区：[1]教育部重要遗传病基因资源利用重点实验室,安徽医科大学人兽共患病省级重点实验室,合肥230032 [2]安徽医科大学附属省立医院检验科,合肥230001

出　　处：《国际医学寄生虫病杂志》2007年第6期306-310,共5页International JOurnal of Medical Parasitic Diseases

基　　金：国家自然科学基金（No.30170841）

摘　　要：血吸虫病是严重危害人类健康的人兽共患寄生虫病，疫苗是预防控制血吸虫病的重要手段。为提高血吸虫病疫苗的免疫效果，国内外通过不同抗原基因的连接、不同疫苗抗原的组合或从噬菌体肽库中筛选到若干个不同抗原表位的混合等途径，来实现复合疫苗或多种单一疫苗的联合免疫，并取得较好的成果。Schistosomiasis is a serious health-threatening parasitic zoonoses to human beings. Vaccine plays an important role in preventing and controlling the disease. Improving vaccine efficacy against schistosomiasis can be achieved by multivalent vaccines or cocktail univalent vaccine. Combined immunization was realized by connection of different antigen sequences, combination of different antigen proteins or mixture of different epitopes screened from the phage peptide library. Progress has been made towards development of vaccines against schistosomiasis with effective protection and long-lasting immunity.

关 键 词：血吸虫病 联合免疫 日本血吸虫 DNA疫苗 免疫机制 

分 类 号：R186[医药卫生—流行病学]