利用多体素氢质子磁共振波谱推测死亡时间  

Estimation of Postmortem Interval with Multivoxel -voxel Proton ^1H -MR Spectroscopy

作　　者：杨天潼[1] 李振伟[2] 刘良[1] 郑娜[1] 

机构地区：[1]华中科技大学同济医学院法医学系,湖北武汉430030 [2]华中科技大学同济医学院附属同济医院放射科,湖北武汉430030

出　　处：《法医学杂志》2007年第6期405-408,共4页Journal of Forensic Medicine

摘　　要：目的利用多体素氢质子磁共振波谱推断死亡时间。方法选取12只白兔,利用多体素磁共振波谱测定死后0.5、1、2、4、6、8、12、16、24h脑内N-乙酰天冬氨酸、胆碱复合物及磷酸肌酸和肌酸的代谢值。结果在死后24h内Naa/Cr、Naa/Ch随死亡时间的延长而降低;Ch/Cr先升高再下降,然后持续升高。结论经多体素质子磁共振研究,Naa/Cr、Naa/Ch、Ch/Cr死后改变呈现一定规律,可用于推断死亡时间。Objective The purpose of our study was to evaluate the postmortem interval with multi-voxel ^1H-MR spectroscopy. Methods Twelve healthy rabbits were studied and the quantities of N-acetylaspartate, total choline, phosphocreatine and creatine were measured by ^1H-MR spectroscopy after death at 0.5, 1, 2, 4, 6, 8, 12, 16, and 24 h. Results The levels of Naa/Cr and Naa/Ch decreased following death, while the level of Ch/Cr increased initially and then decreased following death. Conclusion Muhi-voxel proton MR spectroscopy for Naa/Cr and Ch/Cr metabolic ratio could be used in future postmortem interval studies.

关 键 词：法医病理学 死亡时间 磁共振波谱分析 

分 类 号：DF795.1[医药卫生—法医学]