头孢呋辛钠与临床常用输液的配伍稳定性  

Stability of Cefuroxime sodium with the common used liquid in the clinical

作　　者：王志强[1] 张梅君[1] 金小慧[1] 

机构地区：[1]浙江温州医学院附属第一医院药剂科,温州325000

出　　处：《海峡药学》2007年第12期17-18,共2页Strait Pharmaceutical Journal

摘　　要：目的建立头孢呋辛钠的含量测定方法,研究头孢呋辛钠与4种常用输液的配伍稳定性。方法采用RP-HPLC法测定头孢呋辛钠的含量,同时考察其外观、颜色、pH值变化。结果室温下放置6h,其含量、pH值、外观均无明显变化。结论头孢呋辛钠与4种输液配伍在6h内稳定。OBJECTIVE To establish method for the assay of Cefuroxime sodium , and to investigate the stability between Cefuroxime sodium and the four common used liquid in the clinical. METHODS RP-HPLC was used to determinate the content of Cefuroxime sodium and the appearance, color variety and pH were investigated in the same time. RESULTS The content, pH, appearance of the infusions have not changed significantly after being put in the room temperature for 6 hours. CONCLUSION The four kinds of infusions mixed with Cefuroxime sodium were stable within 6 hours.

关 键 词：头孢呋辛钠 高效液相色谱 稳定性 

分 类 号：R927.11[医药卫生—药学]