他莫昔芬致严重肝损伤  

Severe hepatic injury induced by Tamoxifen

作　　者：申戈[1] 江泽飞[1] 宋三泰[1] 吴世凯[1] 王涛[1] 张少华[1] 卢新友[1] 曾敏[1] 

机构地区：[1]军事医学科学院307医院乳腺癌内科,北京100071

出　　处：《药物不良反应杂志》2007年第6期413-413,419,共2页Adverse Drug Reactions Journal

摘　　要：1名44岁女性乳腺癌患者,于手术及化疗后服用他莫昔芬20mg/d作为辅助内分泌治疗。3个月后患者ALT、AST、γ-GT值升高,服用6个月时患者肝功能检查显示:ALT396U/L、AST278U/L、γ-GT211U/L。经保肝治疗后好转,后改用阿那曲唑、戈舍瑞林治疗,未再出现肝功能异常。A 4.4-year-old women with breast cancer was treated with oral tamoxifen 20 mg/d as adjuvant endocrine therapy after breast operation and chemotherapy. Three months later, her levels of ALT, AST, and γ-GT increased. After 6 months of medication, her liver function examination showed the levels as follows： ALT 396 U/L, AST 278 U/L, and γ-GT 211 U/L. After liver-protective treatment, her hepatic function returned to normal limits. Then she was treated with anastrozole and goserelin instead of tamoxifen, and liver dysfunction did not recur.

关 键 词：他莫昔芬 肝损伤 

分 类 号：R595.3[医药卫生—内科学]