甲乙型肝炎联合疫苗不同浓度的免疫效果观察  

OBSERVATION ON IMMUNE EFFECTS OF THE COMBINED HEPATITIS A AND B VACCINE AT DIFFERENT CONCENTRATIONS

作　　者：马波 练幼辉 谭顺革 何丽芳 杨丽 吴绍学 沈佳航 张刚华 

机构地区：[1]云南沃森生物技术有限公司,昆明650116

出　　处：《现代预防医学》2008年第1期124-125,共2页Modern Preventive Medicine

摘　　要：[目的]寻找甲乙型肝炎联合疫苗不同浓度的免疫方案。[方法]按照3个浓度(1、2、5)剂型组的甲乙型肝炎联合疫苗,分别免疫1、2、5 3个剂型组(疫苗组)、阳性和阴性对照组动物,免疫后28 d采血,检测抗-HAV、抗-HBsAb抗体。[结果]血清抗体阳转率分别为:1组,抗-HAV 90%、抗-HBsAb 60%;2组,抗-HAV100%、抗-HBsAb 60%;5组,抗-HAV 70%、抗-HBsAb 50%。[结论]甲乙型肝炎不同浓度的联合疫苗具有良好的安全性和免疫原性,值得进一步研究。[Objective] To find a immunization program of combined hepatitis A and B vaccine at diffrent concentrations. [Methods] Used combined hepatitis A and B vaccine at the three concentrations to immunize 3 group （vaccine group the positive and the negative group）. 28 days after immunization, anti-HAV, anti-HBsAb in blood were detected. [ Results] The positive rates of serum antibody were as follows： group 1, anti-HAV 90%, anti-HBsAb 60% ; group 2, anti-HAV 100%, anti-HBsAb 60%; group 5, anti-HAV 70%, anti-HBsAb 50%. [Conclusion] Different concentrations of the combined hepatitis A and B vaccine have the good safety and immunogenicity, and it is worthy of further studying.

关 键 词：甲型肝炎 乙型肝炎 甲乙型肝炎联合疫苗 

分 类 号：R512.6[医药卫生—内科学]