叶枯唑原药对大鼠的亚慢性经口毒性研究  

STUDY ON THE SUBCHRONIC ORAL TOXICITY OF BISMERTHIAZOL ON RATS

作　　者：熊静芳[1] 徐培渝[1] 王正书[1] 庞定国[1] 

机构地区：[1]四川大学华西公共卫生学院毒理学教研室,成都610041

出　　处：《现代预防医学》2008年第1期127-129,共3页Modern Preventive Medicine

摘　　要：[目的]研究叶枯唑原药对大鼠的主要亚慢性毒性作用,确定最大无作用剂量及毒作用靶器官。[方法]按照GB15670-1995《农药登记毒理学试验方法》中大鼠亚慢性经口毒性试验方法进行,设0,7.0,27.9,111.7,447.0mg/kg 5个剂量组。[结果]与对照组相比,高剂量组(447.0 mg/kg)体重增长明显减慢(P﹤0.01);脏器系数检查显示低、中、高剂量组甲状腺脏体比均较对照组高(P﹤0.01);组织病理学检查见低、中、高剂量组大鼠甲状腺不同程度的增生,且呈现良好的剂量-反应关系。[结论]大鼠经口染毒叶枯唑原药90 d的最大无作用剂量雌雄鼠均为7.0mg/kg,甲状腺为叶枯唑毒作用的靶器官。[Objective] To study the subchronic toxicity of bismerthiazol on rats and to obtain its NOAEL and targeted organs. [Methods] According to the subchronic oral toxicity testing method listed in the Toxicological Testing Methods for PesticideRegistration （GB15670-1995）, 5 doses groups （0, 7.0, 27.9, 111.7, 447.0 mg/kg） were set up. [Results] The body weights of rats in high dose group （447.0 mg/kg） were significantly less than those of the groups （P 〈 0.01 ） ; the ratios of thyroid gland weights in 27.9, 111.7. 447.0 mg/kg group were higher than that in the control group, and pathological examination showed that thyroid glands had different hyperplasia degrees in all groups and a good dose-response relationship. [Conclusion ] The 90 days NOAEL of bismerthiazol is 7.0 mg/kg in both female and male rats, and targeted organ of toxic effects is thyroid gland.

关 键 词：叶枯唑 亚慢性 经口毒性 

分 类 号：R965.3[医药卫生—药理学]