豆根管食通颗粒质量标准研究  

Study on quality standards of Dougenguanshitong granule

作　　者：郑玉玲[1] 李淑荣[2] 张雁冰[2] 

机构地区：[1]郑州大学第一附属医院,郑州450052 [2]郑州大学药学院,郑州450001

出　　处：《中华中医药杂志》2008年第1期27-31,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：河南省杰出人才创新基金项目(No.0521002600)

摘　　要：目的:建立豆根管食通颗粒的质量标准以控制药品质量。方法:采用薄层层析(TLC)法对颗粒中的三七、黄药子进行鉴别;用HPLC法测定颗粒中苦参碱含量。结果:TLC法检测三七、黄药子具有很强的专属性,苦参碱在0.68-10.2μg范围内线性关系良好(r=0.9997,n=6)。平均加样回收率为100.23%,RSD为1.54%。结论:所建鉴别方法专属性强,定量方法简便、准确,可用于豆根管食通颗粒的质量控制标准。Objective： To establish the standard for the quality control of Dougenguanshitong granule. Methods： The TCL method was used to identify the Radix Ootoginseng and Dioscorea Bulbifera in the granule and the content of matrine in the granule was determined by the HPLC method. Results： The linear relationship of matrine was the range of 0.68 - 10.2μg（ r = 0. 9997, n = 6）. The average recovery was 100.23% and RSD was 1.54% （ n = 6）. Conclusion：The method is convenient, rapid, accurate and suitable for the quality control of Dougenguanshitong granule.

关 键 词：豆根管食通颗粒 质量标准 薄层鉴别 HPLC法 苦参碱 

分 类 号：R286[医药卫生—中药学]