荜澄茄等3种挥发油对乌头碱经皮渗透的影响  

Effect of three volatile oils on percutaneous penetration of aconitine through mouse skin in vitro

作　　者：李艳杰[1] 白一岑[1] 马云淑[1] 

机构地区：[1]云南中医学院中药学院,昆明650200

出　　处：《中华中医药杂志》2008年第1期40-42,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.30560187)

摘　　要：目的:研究荜澄茄、干姜、石菖蒲挥发油对乌头碱经皮渗透的影响。方法:采用改良Franz扩散池法,以HPLC法测定模型药物乌头碱的累积渗透量,考察不同浓度的荜澄茄、干姜、石菖蒲挥发油对乌头碱的促渗效果。结果:7%浓度的荜澄茄、干姜、石菖蒲挥发油与3%氮酮的渗透系数(×10-3cm/h)分别为:10.79、5.82、5.40、3.91,与无促渗剂的对照组比较,差异均具有显著性意义,促渗倍数分别为3.87、2.09、1.94、1.40倍,可见7%的3种挥发油促渗倍数均大于3%氮酮。结论:7%的荜澄茄、干姜、石菖蒲挥发油均能明显促进乌头碱的经皮渗透。Objective： To study the effect of volatile oil of Fructus Litseae（FL） , Rhizoma Zingiberis（RZ） and Rhizoma Acori Talarinowii （RAT） on percutaneous penetration of aconitine through mouse skin in vitro . Methods ： By using improved Franz diffusion cells , the effects of these 3 volatile oils on the percutaneous penetration of aconitine were observed and compared with azone , and the cumulative amount of aconitine was determined by HPLC. Results ： The penetration coefficient of aconitine with 7 % （v/v） volatile oil of FL, RZ and RAT and 3 % azone were 10.79,5.82,5.40,3.91, respectively; Compared with the group without penetration enhancers, the differences were significannt; and the enhancement ratios were 3.87,2.09, 1.94 and 1.40, respectively, which showed the enhancement ratios of 7 % of the 3 volatile oils were higher than that of 3 % azone . Conclusion ： The 7 % volatile oils of FL, RZ and RAT enhance the permeation of aconitine effectively.

关 键 词：促渗剂 乌头碱 荜澄茄油 干姜油 石菖蒲油 

分 类 号：R284[医药卫生—中药学]