血塞通对兔下肢缺血再灌注自由基信号的影响  

Effect of Xuesaitong on lower limb of rabbit ischemia-reperfusion free radical

作　　者：刘继前[1] 安荣姝[2] 尚宪荣[1] 曹建春[1] 曹刚[1] 陈朝晖[1] 

机构地区：[1]北京中医药大学东方医院,北京100078 [2]中日友好医院,北京100029

出　　处：《中华中医药杂志》2008年第1期62-64,共3页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:探讨血塞通对下肢缺血再灌注损伤的保护作用。方法:采用电子自旋共振技术和电子自旋共振捕集技术(N-tert-butyl-2-phenylnitrone,PBN)观察兔下肢缺血再灌注时出现PBN-自旋加合物信号。结果:该信号强度与缺血时间有关,缺血4h再灌注时的信号明显强于缺血2h再灌注;血塞通对该自旋加合物信号有明显猝熄作用。结论:血塞通对下肢缺血再灌注损伤具有一定的保护作用。Objective： To investigate the protective effect of Xuesaitong （total saponins of sanchi） on lower extremity ischemical reperfusion injury. Methods： To observe PBN -spin bulky adducts signal of lower extremity ischemical reperfusion of rabbit by using electron spin resoance technology and electron spin resonance promoter N-tert-butyl-2-phenylnitrone （PBN）. Results： The signal intensity is correlated with time, compared with ischemia for 2 hours, the signa/intensity of ischemia for 4 hours increased apparently. Xuesaitong would quench PBN -spin bulky adducts signal significantly. Conclusion： Xuesaitong have protective effect on lower extremity ischemia-reperfusion injury.

关 键 词：三七总皂苷(血塞通) 游离基类 电子自旋共振 实验研究 

分 类 号：R285.5[医药卫生—中药学]