GDNF对精原干细胞增殖及其分化的调控机制  

Roles of GDNF in the Proliferation and Differentiation of Spermatogonial Stem Cells

作　　者：刘姗姗[1] 李树峰[1] 李丹丹[1] 杨丹[1] 严云勤[1] 

机构地区：[1]东北农业大学生命科学学院组织胚胎学教研室,哈尔滨150030

出　　处：《细胞生物学杂志》2007年第6期831-834,共4页Chinese Journal of Cell Biology

摘　　要：阐述了胶质细胞源性神经营养因子(GDNF)及其受体与精原干细胞增殖和分化的关系。GDNF能够促进未分化的精原细胞增长,并且可以调节精原干细胞自我更新与分化的微环境,参与其分化的第一步,是精原干细胞存活的重要营养因子。The roles of glial cell line-derived neurotrophic factor （GDNF） and its receptors during the processes of proliferation and differentiation in spermatogonial stem cells were reviewed in this article. It has been proved that GDNF gets involved in the activation of undifferentiated spermatogonia growth, the regulation of the micro-environment of spermatogonial stem cell self-renewal/differentiation and the participation in the first step of differentiation. According to these researches, GDNF is an important nutritional factor in the survival of spermatogonial stem cells.

关 键 词：胶质细胞源性神经营养因子 精原干细胞 自我更新 分化 

分 类 号：Q2[生物学—细胞生物学]