Role of fibroblast growth factor receptor 1 in the bone development and skeletal diseases  

作　　者：李福兵 杜晓岚 陈林 

机构地区：[1]State Key Laboratory of Trauma,Burns and Combined Injury,Trauma Center,Institute of Surgery Re-search.Duping Hospital.Third Military Medical University

出　　处：《Journal of Medical Colleges of PLA(China)》2007年第6期376-384,共9页中国人民解放军军医大学学报（英文版）

基　　金：the National Key Basic Research and Devel opment Plan of China(973 Projects,2005CB522604);the Research Project of Scientific Committee of Chongqing(2004BA5016)

摘　　要：Accumulating data suggest that FGFs/FGFR1 plays essential roles in the bone development and human skeletal diseases. Conditional inactivation of fgfrl caused different phenotypes displaying in different cells or specific organs and revealed some novel functions of FGFR1 in bone development. Fgfrl mutation mainly induced 2 types of human skeletal diseases, craniosynostosis syndrome and dysplasias. Similar mutation of fgfrl in mouse model just mimicked the phenotype that happened in human. These fa- cilitate the investigation on the underlying mechanism of the diseases. Here we mainly focused on the ad- vance of FGFR1 function in the bone development and its mutation caused skeletal diseases.Accumulating data suggest that FGFs/FGFR1 plays essential roles in the bone development and human skeletal diseases.Conditional inactivation of fgfr1 caused different phenotypes displaying in different cells or specific organs and revealed some novel functions of FGFR1 in bone development.Fgfr1 mutation mainly induced 2 types of human skeletal diseases,craniosynostosis syndrome and dysplasias. Similar mutation of fgfr1 in mouse model just mimicked the phenotype that happened in human.These fa- cilitate the investigation on the underlying mechanism of the diseases.Here we mainly focused on the ad- vance of FGFR1 function in the bone development and its mutation caused skeletal diseases.

关 键 词：fibroblast growth factor receptor 1 bone development skeletal disease conditional inactivation bone fracture 

分 类 号：R681[医药卫生—骨科学]