传染性单核细胞增多症患者血清TNF-α，IL-18水平的临床意义  

Clinical Significance of Serum Levels of TNF-αand IL-18 in Patients with Infectious Mononucleosis

作　　者：王洪青[1] 宋士洪[1] 张淑华[1] 宗慧[1] 

机构地区：[1]山东滕州市中心人民医院检验科,山东滕州277500

出　　处：《标记免疫分析与临床》2007年第4期221-222,233,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：探讨血清细胞因子与传染性单核细胞增多症(IM)病变的关系。在不同时相点(IM发病期,恢复期)采用RIA检测TNF-α,采用ELISA检测IL-18水平。结果是IM患者血清TNF-α,IL-18水平明显高于对照组(P<0.01),发病期IM患者血清TNF-α,IL-18水平高于恢复期IM患者,IM患者发病期间血清TNF-α,IL-18水平升高程度与病情有关。血清TNF-α,IL-18水平变化是判断传染性IM患者免疫状态,评估预后的重要指标。To explore the relationship between serum cytokine and infectious mononucleosis （IM）, the levels of serum TNF-α and IL-18 in patients with infectious mononucleosis and healthy control were measured by RIA and ELISA respectively at various time point of attack and restoration stage. The results showed that the levels of serum TNF-α and IL-18 in patients with IM were significantly higher than that in control （P〈0.01）. The serum levels of TNF-α and IL-18 in patients at attack stage were significantly higher than that of at restoration stage （P〈0.01）. The levels of serum cytokine were correlated with the state of illness. The serum cytokine TNF-α and IL-18 may be regarded as index to reflect the state of immunity and prognosis of patients with IM.

关 键 词：传染性单核细胞增多症 肿瘤坏死因子-Α 白介素-18 

分 类 号：R725.1[医药卫生—儿科]