流动注射光化学荧光法测定药物制剂中的盐酸氯丙嗪  

Flow Injection Photochemical-Spectrofluorimetric Determination of Chlorpromazine in Pharmaceutical Preparations

作　　者：朱京平[1] 陈恒武[2] 方琼君 

机构地区：[1]杭州大学中心实验室 [2]杭州大学化学系,杭州310028

出　　处：《分析化学》1997年第5期573-575,共3页Chinese Journal of Analytical Chemistry

基　　金：浙江省分析测试基金资助项目

摘　　要：氯丙嗪的流动注射光化学反应在一编结反应器中进行，该反应器盘绕在一荧光灯上并接受由该灯发出的最大幅射波长为３６５ｎｍ的紫外线照射。用２５３．０ｎｍ的激发波长和３７４．５ ｎｍ的荧光波长在线测定光化学反应产物的荧光强度。在最佳条件下，检测限（３σ）为５．４μｇ／Ｌ，采样速率为９０次／ｈ，１ｍｇ／Ｌ的分析物１１次测定的相对标准偏差为０．５％，动态线性范围为０．０１～６．００ｍｇ／Ｌ。所建立的方法已成功地用于片剂和针剂中盐酸氯丙嗪含量的测定。Flow injection-photochemical reaction of chlorpromazine was carried out in a knot- ted reactor that was coiled around a fluorescent lamp and irradiated by its UV light with the emission maximum at 365 nm. The fluorescence of the photochemical reaction product was on-line measured at the excitation wavelength of 253 nm and the emission wavelength of 374. 5 nm. Under the optimized condition,a detection limit (3σ) of 5. 4 μg/mL was achieved at a sample throughput rate of 90/h,and a relative standard deviation of 0. 5% obtained at the analyte concentration of 1 mg/L (n= 11). Linear dynamic range was 0. 01 -6. 00 μg/L. The proposed mothed has been successfully appllied to the determination of chlorpromazine hy- drochloride contents in tablets and injections.

关 键 词：氯丙嗪 光化学荧光法 流动注射分析 荧光 

分 类 号：R971[医药卫生—药品]