血栓靶向性超声微泡治疗犬急性冠脉血栓  

Thrombus target ultrasound microbubbles for treatment of acute coronary artery thrombosis of dog

作　　者：陈小敏[1] 区文超[1] 孙德胜[1] 宫琳[1] 刘俐[1] 王双双[1] 

机构地区：[1]北京大学深圳医院超声影像科,广东深圳518036

出　　处：《基础医学与临床》2007年第12期1339-1342,共4页Basic and Clinical Medicine

基　　金：广东省自然科学基金博士启动科研基金(5300271)

摘　　要：目的探讨自制血栓靶向超声微泡造影剂对犬急性冠脉血栓的溶栓作用。方法建立犬心脏左前降支急性血栓模型,经下肢股静脉恒速注射自制脂质血栓靶向微泡(TMB)或白蛋白微泡(AMB),同时予1 MHz、2.0 W/cm2超声(US)照射,记录前降支血流量变化;分别用图像分析及硝基四氮唑蓝染色的方法检测管腔残存血栓面积和心肌梗死范围。结果TMB+US组血管再通时间及相应的残余血栓和梗死面积均显著小于AMB+US(P<0.05);但仍然稍大于尿激酶(UK)组;而TMB+UK+US组上述指标则明显优于单纯UK组。结论在1 MHz超声作用下,自制血栓靶向性微泡对急性冠脉血栓的溶解作用显著优于人血白蛋白微泡。Objective To evaluate the efficacy of acute coronary arterial clot disruption by intravenous administration of self-restraint thrombus target ultrasound microbubbles（TMB）. Methods Thrombus was formed in the left descent coronary artery by electrical stimulation in 25 dogs. After thrombolysis, dogs received treatment by transcutaneous ultrasound （1 MHz,2.0 W/cm^2） and TMB or albumin microbubbles （AMB）. The vessel recanalization time was recorded and the areas of residual thrombus and infarction were compared by pathological section. Results TMB intravenous administrated resulted in quick recovery of arterial embolism and decreased the thrombus ratio of residual thrombus cross-sessional and infarction area compared with AMB groups. The effect of thrombolysis was significantly progressed in TMB plus half dose urokinase group and even better than that in urokinase groups. Conclusion The thrombolytics activity of TMB was superior to AMB when combines with 1 MHz ultrasonic beam.

关 键 词：超声 微泡 溶栓 心肌梗死 

分 类 号：R543.3[医药卫生—心血管疾病]