清炎颗粒对肾盂肾炎小鼠外周血IL-8与IL-10的影响  

Effect of Qingyan Granula on IL-8 and IL-10 Releasing in Mice with Pyelonephritis

作　　者：沈惠风[1] 汤璐敏[1] 王利民[1] 李鹤[1] 李祎群[1] 

机构地区：[1]上海交通大学医学院附属仁济医院,上海200127

出　　处：《中国中西医结合肾病杂志》2007年第12期701-703,共3页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：上海市科学技术发展基金资助项目(No034119923)

摘　　要：目的:探讨清炎颗粒治疗肾盂肾炎的免疫学机制。方法:采用孙氏方法改进造模,治疗组分别按剂量3.12、6.24、12.48g.kg-1.d-1予清炎颗粒,模型组予生理盐水,对照组予至灵胶囊灌胃,喂养至3d、7d、15d、30d、60d取血清,用ELISA法检测其IL-8、IL-10的水平。结果:清炎颗粒能显著降低不同时段血清IL-8的水平、提高不同时段血清IL-10的水平。结论:免疫调控可能是清炎颗粒治疗肾盂肾炎的作用机制之一。Objective：To investigate the mechanism of Qingyan Granula in treating pyelonephritis, Methods：The mice model of pyelonephritis was established by incomplete unilateral ureter obstruction. Results： The serum IL- 8, IL- 10 in normal group, model group, control group（ Zhiling capsule）and Qingyan Granula groups（3.12,6.24,12.48 g·kg^-1·d^-1） were measured at 3rd day,7 th day,15 th day,30th day and 60th day by ELISA. Results The serum IL- 8 in Qingyan Granula groups was significantly lower than that in model group （P〈0.05） in different timepoints while the serum IL- 10 was significantly higher（P〈0.05）. Conclusion： Immunoregulation is one of the possible mechanisms of Qingyan Granula in treatment of pyelonephritis.

关 键 词：肾盂肾炎 清炎颗粒 白细胞介素-8 白细胞介素-10 

分 类 号：R285.5[医药卫生—中药学]