SUMO化反应在肾脏疾病中的作用探索  

Exploration on effects of sumoylation on kidney diseases

作　　者：朱冰冰[1] 王伟铭[1] 陈楠[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院肾脏科,上海200025

出　　处：《国际内科学杂志》2007年第12期732-735,739,共5页International Journal of Internal Medicine

基　　金：国家自然科学基金资助项目(30270613);上海市卫生局重点学科基金(05Ⅲ001);上海市重点学科(T0201);上海市卫生局重点课题(2003ZD002)

摘　　要：小泛素相关修饰物(SUMO)与靶蛋白的共价结合是一种真核基因表达的翻译后加工形式。SU-MO化能够使蛋白质更加稳定,进而调节许多关键的细胞活动,如核运输、信号传递、凋亡、细胞周期调控以及基因表达的调控等。此外SUMO化还可通过过氧化物酶体增殖物激活受体-γ、核转录因子-κB及转化生长因子-β依赖的途径参与抗炎和致纤维化过程,本文就这一机制可能在肾脏疾病中发挥的作用作一综述。Covalent bonding of small ubiquitin related modifier （SUMO） with its substrate proteins is a form of post-translational modifications of eukaryotic gene expression. Sumoylation could enhanee the stability of protein, thus modulate a number of key cellular processes such as nuclear transport, transcriptional regulation, apoptosis and control of cell cycle and gene expression. Additionally, recent findings demonstrate that sumoylation participates in the processes of anti-inflammation and fibrosis by peroxisome proliferatorsactivated receptorgamma, NF-kappaB and transforming growth factor-beta pathways, which may play an important role in kidney diseases. This review focuses on the mechanism of these effects in kidney disease.

关 键 词：小泛素相关修饰物 过氧化物酶体增殖物激活受体-Γ 核转录因子-ΚB 转化生长因子-β肾脏疾病 

分 类 号：R692[医药卫生—泌尿科学]