盐酸伊立替康脂质体制备的影响因素考察  

Study on preparation of irinotecan hydrochloride liposomes and its influence factors

作　　者：杨建坤[1] 刘宏伟[1] 张俭俭[2] 谢瑞娟[1] 刘慧光[1] 曹德英[3] 

机构地区：[1]河北大学附属医院药剂科,保定071000 [2]中国人民武装警察部队学院医院药剂科,廊坊065000 [3]河北医科大学药学院,石家庄050017

出　　处：《中国新药杂志》2007年第23期1962-1964,共3页Chinese Journal of New Drugs

摘　　要：目的:对盐酸伊立替康的脂质体制备方法进行考察。方法:在预实验的基础上初步确定盐酸伊立替康脂质体的制备方法和处方,然后通过单因素考察初步确定影响脂质体制备的因素。结果:硫酸铵梯度法制备的盐酸伊立替康脂质体包封率较高(75.40%),且能保持药物活性。结论:采用硫酸铵梯度法制备脂质体给药系统,制备工艺简单,重现性好,质量稳定,是一种很有前途的靶向给药系统。Objective ： To optimize the preparation method of irinotecan hydrochloride （ CPT-11 ） liposomes by the entrapment efficiencies. Methods ： On the basis of preliminary experiments, CPT-11 li- posome preparation methods were evaluated and then the single factor prescription were used for the identification of factors affecting CPT-11- liposome preparation. Results： The ammonium sulfate gradient method was used to prepare CPT-11 and get higher entrapment efficiency（75.40% ）. Conclusion：Ammonium sulfate gradient method for CPT-11 liposome preparation is simple and efficient.

关 键 词：盐酸伊立替康 脂质体 硫酸铵梯度法 包封率 

分 类 号：R943.42[医药卫生—药剂学] R979.1[医药卫生—药学]