用水迷宫实验检测甲醛对小鼠的神经毒性  

Morris water maze test for neurooxicity induced by formaldehyde in mice

作　　者：周砚青[1] 常亮[2] 王昆[2] 

机构地区：[1]华中师范大学汉口分校 [2]华中师范大学生命科学学院

出　　处：《公共卫生与预防医学》2007年第6期4-6,共3页Journal of Public Health and Preventive Medicine

基　　金：国家科技支撑计划项目(2006BAI19B05和2006BAJ02A10);湖北省教育厅教学研究项目(20050193)

摘　　要：目的为了探讨环境污染物甲醛的神经毒性。方法采用浓度为10.0mg/kg的液态甲醛和生理盐水对小鼠进行腹腔注射式染毒,随后进行Morris水迷宫实验(游泳训练)。结果实验显示,10.0mg/kg甲醛染毒组与对照组实验结果之间有显著差异。结论提示较高浓度的甲醛可能对哺乳动物具有一定的神经毒性。Objective To explore the neurotoxicity induced by environmental pollutant formaldehyde. Methods After exposed to 10.0mg/kg of liquid formaldehyde by the way of intraperitoneal injection, the mice were tested with Morris water maze. Results It showed that there was significant difference in the water maze performance between 10. 0 mg/kg formaldehyde injected group and saline injected group （ control group）. Conclusion It is suggested that formaldehyde may have neurotoxicity to mammal animals.

关 键 词：甲醛 神经毒性 MORRIS水迷宫实验 

分 类 号：R135.14[医药卫生—劳动卫生]