流动注射增强鲁米诺-高碘酸钾体系化学发光法测定阿莫西林钠  

Determination of Amoxicillin Sodium Based on Its Enhancing Effect on the Luminol Postassium Periodate System Using Flow Injection Chemiluminescence

作　　者：石文兵[1] 杨季冬[1] 范春蕾[2] 张君[1] 

机构地区：[1]长江师范学院化学及环境科学系,重庆涪陵408003 [2]海南大学公共实验中心,海南海口570228

出　　处：《海南大学学报（自然科学版）》2007年第4期353-356,共4页Natural Science Journal of Hainan University

基　　金：重庆市教委资助项目（KJ061306）;重庆市科技攻关计划项目（CSTC,2006AA7003）;发光与实时分析重庆市重点实验室开放基金项目;长江师范学院资助项目（05flsy022）

摘　　要：在NaOH介质中，高碘酸钾氧化鲁米诺产生化学发光，阿莫西林钠显著增强该体系的发光，据此，建立了一种简单、快速测定阿莫西林钠的流动注射化学发光新方法．在优化的试验条件下，线性范围为0．01—20mg·L^-1，检出限（3σ）为2．6μg·L^-1，对1．0mg·L^-1阿莫西林钠进行了11次平行测定，其相对标准偏差为2．4％．将本法用于粉针剂、合成样品及尿样中阿莫西林钠的测定，结果令人满意．The light emission produced by means of the oxidation of luminol using postassium periodate in the basic medium was enhanced by amoxicillin sodium. A new, simple and rapid method has been developed for the determination of amoxicillin sodium in this paper. In the optimum conditions, CL intensities are proportional to the concentrations of amoxicillin sodium in the 0.01 - 20 mg · L^- 1 range. The limit of detection is 2.6 μg · L^- 1 for amoxicillin sodium and the relative standard deviation （RSD） is 2.4% for 1.0 mg · L^- 1 amoxicillin sodium （ n = 11 ）. The method has been applied in the determination of amoxicillin sodium in the commercial preparations, injection, synthetically samples, and urine samples with satisfactory results.

关 键 词：化学发光 流动注射分析 阿莫西林钠 

分 类 号：O657.3[理学—分析化学]