脂多糖和某些致炎细胞因子对培养人内皮细胞形态与功能的影响  

Effects of LPS, IL-1β and IFN-γ on morphological and functional changes of cultured human aortic endothelial cells

作　　者：唐海兰[1] 林白霜[2] 颜亮[2] 

机构地区：[1]暨南大学医学院组织胚胎学教研究,广州510632 [2]暨南大学医学院病理生理学教研室,广州510632

出　　处：《中国病理生理杂志》1997年第4期364-367,共4页Chinese Journal of Pathophysiology

基　　金：国务院侨办重点学科科研基金

摘　　要：在脂多糖,白细胞介素-1β和干扰素-γ作用下,培养人主动脉内皮细胞的形态和一氧化氮合成酶活性出现明显改变。一氧化氮合成酶活性在作用6小时后显著增高,此时细胞开始出现梭形化变化。作用10小时形态改变最明显,细胞明显变长,长宽比较正常对照增加两倍以上,而此时一氧化氮合成酶活性已降至和对照组无明显差异。The significant changes in morphology and nitric oxide synthase (NOS) activity in cultured human aortic endothelial cells (HAEC) were observed when these cells were exposed to LPS, IL-1β and IFN-γ. NOS activity increased at 6h of treatment, the time point that HAEC began to change and elongate. The cell shape became fibroblast like and the length to width ratio of the cells increased 2 times of that of the control at 20h treatment, the time point that NOS activity returned to control level.

关 键 词：脂多糖类 内皮细胞 致炎细胞因子 内毒素血症 

分 类 号：R515.302[医药卫生—内科学]