川芎嗪舒血管作用的部位差异性及其对钙释放的抑制  

Regional difference of tetramethylpyrazine in vasorelaxation and its inhibitory effect on Ca 2+ release

作　　者：黄燮南[1] 

机构地区：[1]遵义医学院药理学教研室

出　　处：《中国药理学与毒理学杂志》1997年第3期199-201,共3页Chinese Journal of Pharmacology and Toxicology

摘　　要：川芎嗪（ＴＭＰ，０．０１－２．０ｍｍｏｌ·Ｌ－１）呈浓度依赖性地舒张犬的多种离体血管条，其中舒张股动脉的强度是冠状动脉的３．３倍；在肠系膜动脉，ＴＭＰ对前列腺素Ｆ２α及高浓度ＫＣｌ预收缩的动脉条均有舒张作用，但对前者的作用强度约为后者的５．６倍；在无Ｃａ２＋液中，ＴＭＰ呈浓度依赖性地抑制苯福林的缩血管作用而不影响咖啡因的效应．结果表明：（１）ＴＭＰ的扩血管作用具有部位差异性；（２）ＴＭＰ不具备典型钙拮抗剂的特点；（３）ＴＭＰ可能对受体中介的钙释放有一定的选择性抑制．The vasorelaxing effects of tetramethylpyrazine (TMP) were tested in dog isolated mesenteric, femoral, coronary, renal and basilar artery strips precontracted with pros taglandin F 2α (PGF 2α 0.5 μmol·L 1 ). The results showed that TMP was 3.3 fold as potent in fem oral artery as in coronary artery. In mesenteric artery, it was 5.6 fold as potent in the strips precontracted with PGF 2α as with KCl 20 mmol·L 1 . Furthermore, TMP inhibited the contractions induced by phenylephrine but not caffeine in Ca 2+ free medium. From the results three proposals are suggested: (1) there may be a regional difference in the vasorelaxant effects of TMP; (2) TMP may not be a calcium blocker; (3) TMP may interference with receptor mediated Ca 2+ release.

关 键 词：川芎嗪 血管扩张药 血管舒张 钙释放 

分 类 号：R285.5[医药卫生—中药学]