吡那地尔和硝苯地平对大鼠离体血管的作用  

Effects of pinacidil and nifedipine on isolated rat arteries 1

作　　者：汪海[1] 路新强[1] 张雁芳[1] 龙超良[1] 王家惠 

机构地区：[1]军事医学科学院毒物药物研究所

出　　处：《中国药理学与毒理学杂志》1997年第3期229-230,共2页Chinese Journal of Pharmacology and Toxicology

基　　金：国家医药技术创新重大项目;军事医学科学院新药研究基金

摘　　要：吡那地尔和硝苯地平对大鼠离体血管的作用１汪海路新强张雁芳龙超良王家惠（军事医学科学院毒物药物研究所，北京１００８５０）吡那地尔（ｐｉｎａｃｉｄｉｌ，Ｐｉｎ）属ＡＴＰ敏感性钾通道激活剂类抗高血压药物，其抗高血压作用的强度，持续时间和反射性加快心率作用等...The vasodilative effects of pinacidil and nifedipine were compared in the isolated preparations of rat arteries. The EC 50 values of pinacidil for dilating the arteries precontracted with potassium chloride at the concentration of 20 or 80 mmol·L 1 , were 9 or 81 times more than those of nifedipine respectively. The EC 50 value of pinacidil for dilating the arteries precontracted with norepinephrine at the concentration of 10 μmol·L 1 was 1/10 of nifedipine. In the calcium free solutions, pinacidil rather than nifedipine could dilate the arteries precontracted with norepinephrine in a concentration dependent manner. It indicated that the antagonistic effects of pinacidil on voltage dependent calcium channels are less potent than those of nifedipine. In addition, pinacidil can depress vasocontractions evoked by intracellular calcium release.

关 键 词：吡那地尔 硝苯地平 扩血管作用 

分 类 号：R972.4[医药卫生—药品]